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Titolo:
MALIGNANT TROPHOBLASTIC NEOPLASMS WITH DIFFERENT MODES OF ORIGIN
Autore:
ARIMA T; IMAMURA T; SAKURAGI N; HIGASHI M; KAMURA T; FUJIMOTO S; NAKANO H; WAKE N;
Indirizzi:
KYUSHU UNIV,MED INST BIOREGULAT,DEPT REPROD PHYSIOL & ENDOCRINOL,4546TSURUMIHARA BEPPU OITA 874 JAPAN KYUSHU UNIV,MED INST BIOREGULAT,DEPT REPROD PHYSIOL & ENDOCRINOL BEPPU OITA 874 JAPAN HOKKAIDO UNIV,FAC MED,DEPT OBSTET & GYNECOL SAPPORO HOKKAIDO 060 JAPAN UNIV RYUKYUS,FAC MED NISHIHARA OKINAWA JAPAN KYUSHU UNIV,FAC MED FUKUOKA 812 JAPAN
Titolo Testata:
Cancer genetics and cytogenetics
fascicolo: 1, volume: 85, anno: 1995,
pagine: 5 - 15
SICI:
0165-4608(1995)85:1<5:MTNWDM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; HYDATIDIFORM MOLE; CELL-LINES; CHORIOCARCINOMA; GENE; DNA; POLYMORPHISMS; AMPLIFICATION; LOCUS; VNTR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
T. Arima et al., "MALIGNANT TROPHOBLASTIC NEOPLASMS WITH DIFFERENT MODES OF ORIGIN", Cancer genetics and cytogenetics, 85(1), 1995, pp. 5-15

Abstract

The genetic origin of 24 trophoblastic neoplasms was determined usingPCR polymorphisms. Based on pregnancy history, these tumors included nine postmolar trophoblastic tumors, 12 tumors preceded by live birth or abortion, and three nongestational tumors. Androgenetic origin was defined in eight postmolar trophoblastic tumors, and the remaining onemight have arisen from a normal fertilization. Six tumors retained genetic features carried by the homozygous complete mole. Two tumors showed PCR polymorphism compatible with that of the heterozygous completemole. All 12 tumors in the second class had alleles of both paternal and maternal contribution. However, discordance of sex between the antecedent pregnancy product and the tumor was recognized in three choriocarcinomas. The absence of paternal contribution suggested a parthenogenetic origin of three nongestational choriocarcinomas. The findings that PCR polymorphisms were either homozygous in certain loci or heterozygous in others may mean that the tumor was derived from a germ cell after meiosis I. As a result, at least three subtypes with different modes of origin were demonstrated in the 24 trophoblastic tumors. Thesefindings underscore the importance of precise genetic marker analysesin a large series to clearly identify clinical and biologic characteristics of each subset of tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:06:03