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Titolo:
FRONTAL-CORTEX ABLATION REVERSIBLY DECREASES STRIATAL ZIF 268 AND JUNB EXPRESSION - TEMPORAL CORRESPONDENCE WITH SENSORY NEGLECT AND ITS SPONTANEOUS-RECOVERY/
Autore:
VARGO JM; MARSHALL JF;
Indirizzi:
UNIV CALIF IRVINE,DEPT PSYCHOBIOL IRVINE CA 92717 UNIV CALIF IRVINE,DEPT PSYCHOBIOL IRVINE CA 92717
Titolo Testata:
Synapse
fascicolo: 4, volume: 22, anno: 1996,
pagine: 291 - 303
SICI:
0887-4476(1996)22:4<291:FARDSZ>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENES; DORSOMEDIAL PREFRONTAL CORTEX; RECEPTOR ANTAGONIST MK-801; C-FOS; DIFFERENTIAL EXPRESSION; BASAL GANGLIA; RAT-BRAIN; PROTEIN-PHOSPHORYLATION; DOPAMINE-D1 RECEPTOR; UNILATERAL LESIONS;
Keywords:
FRONTAL CORTEX; CAUDATE-PUTAMEN; IMMEDIATE EARLY GENE; AMPHETAMINE; CONSTITUTIVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Vargo e J.F. Marshall, "FRONTAL-CORTEX ABLATION REVERSIBLY DECREASES STRIATAL ZIF 268 AND JUNB EXPRESSION - TEMPORAL CORRESPONDENCE WITH SENSORY NEGLECT AND ITS SPONTANEOUS-RECOVERY/", Synapse, 22(4), 1996, pp. 291-303

Abstract

This study's goal is to identify subcortical adaptations that may contribute to recovery of function following cortical injury. After unilateral aspiration of the medial agranular region of frontal cortex (AGm), rats demonstrate neglect of contralateral stimuli and recover within 3-4 weeks. Previous studies indicate that compensatory neural alterations involving dopamine (DA) occur following this cortical injury andthat recovery from neglect produced by frontal injury is accompanied by normalization of glucose utilization within subcortical structures including the basal ganglia. The current study examined Zif and JunB, IEG protein products constitutively expressed in striatum, rendering it possible to investigate the effects of unilateral AGm ablation on striatal function during unstimulated as well as amphetamine-stimulated conditions. Five days after surgery, when contralateral neglect was still evident, the numbers of Zif-like or Jun-like immunoreactive (IR) nuclei in the ipsilateral striata of AGm-ablated rats were reduced. These lesion effects were similar for both constitutive and amphetamine-stimulated IEG expression and were restricted to the dorsolateral caudate-putamen, where excitatory input from AGm is most dense. In contrast, 3 or more weeks after AGm ablation, in rats demonstrating recovery, normal striatal Zif- and JunB-like immunoreactivity occurred. Thus, striatal zif/268 and junB expression is reduced 5 days after AGm injury in rats demonstrating neglect and normalized 3 or more weeks later in recovered rats. These findings indicate that adaptations involving shestriatal medium spiny neuron, a site of convergence of cortical glutamatergic and nigral dopaminergic afferents, may contribute to behavioral recovery following neocortical injury. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:33:34