Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE HOPE (HEART OUTCOMES PREVENTION EVALUATION) STUDY - THE DESIGN OFA LARGE, SIMPLE RANDOMIZED TRIAL OF AN ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR (RAMIPRIL) AND VITAMIN-E IN PATIENTS AT HIGH-RISK OF CARDIOVASCULAR EVENTS
Autore:
MINDLEN F; NORDABY R; RUIZ M; ZAVALA A; GUZMAN L; MARTINEZ F; DIAZ RR; MACKEY C; MARINO M; ROMERO G; ZAPATA G; CUNEO C; KAWAMURA T; COELHO O; MASSAYOCHI O; BRAGA J; LABRUNIE A; BODANESE L; MANENTI E; VITOLA D; NICOLAU J; AMODEO C; ARMAGANIJAN D; BERTOLAMI M; CARAMELI B; CARVALHO A; CIRENZA C; FICHINO M; FRANKEN R; GHORAYEB N; KADRI T; LEAO P; MALHEIROS F; PAVANELLO R; RAMIRES F; RAMIRES J; SAVIOLI F; SOUSA A; TANAJURA L; TOPPS D; KORNER L; MARTINEZ V; BAPTIE B; BASINGER M; BAYLIS B; BERESFORD P; EDWARDS A; GIANNACCARO P; GROENEWOUD Y; GROSE M; KELLEN J; LAM S; LESOWAY R; MA P; MELDRUM D; MITCHELL D; MITCHELL LB; ROTH D; SHUMAK S; SIMON M; STONE J; WARNICA W; WYSE D; NEFFGEN C; NEFFGEN J; ARMSTRONG F; ARMSTRONG W; BELL N; BLACK W; BRASS N; BRENNEIS F; BROWNOFF R; CHAYTORS G; DEBANNE D; DERKSEN C; DONOFF M; DZAVIK V; GOERES M; GREENWOOD P; GULAMHUSEIN S; HUI W; HUTCHISON K; KASIAN L; KASZA L; KRIKKE E; KVILL L; LAKHANI Z; LINKLATER D; MACKEL J; MARTIN S; MONTAGUE T; MOORES D; MUSSEAU A; MUZYKA T; PARADIS J; PROSSER A; RYAN E; SENARATNE M; STENERSON P; TALIBI T; TEO K; YOUNG C; ZUK V; WHITE R; BROWNE K; BROWNE M; HAPPEL K; IRVING A; PLESKO A; DONNELLY R; RADOMSKY N; FELKER P; LARSEN D; MORSE J; ROWNTREE C; THOMPSON J; WEDEL R; BLOOMBERG G; CHOMIN G; DAHL M; LEONG W; MOY V; HEATH J; MARSHALL J; TERWIEL M; KENEFICK G; KURITZKY R; STEVENS K; WEDDINGS K; BARBAN K; IMRIE J; WOO K; ASHTON T; CALVERT K; BISHOP W; SWEENEY R; BREAKWELL L; KORNDER J; PEARCE S; POLASEK P; RICHARDSON P; GHOSH S; RIELLY M; WAGNER K; BEMSTEIN V; DAWSON K; LEE P; LEWIS J; MACDONALD K; MCGEE L; THOMPSON C; HILTON D; ILLOTT K; KLINKE P; MCCONNELL J; MCGEE L; RABKIN S; ONG A; ONG G; BEDARD D; HOESCHEN R; MEHTA P; MOHAMMAD I; MORRIS A; BESSOUDO R; DOBBINS N; MCLELLAN L; MILTON J; DAVIS R; OKEEFE D; SMITH R; JOYCE C; PARSONS M; SKANES J; SUSSEX B; TOBINI M; RAVALIA M; SHERMAN G; WORRALL G; ATKINSON A; HATHEWAY R; JOHNSON B; BARNHILL S; BATA I; COSSEET J; JOHNSTONE D; MACFARLANE M; SHERIDAN W; CROSSMAN L; FOLKINS D; SHIRLEY M; MACHEL T; MORASH J; GUPTA M; MAYICH M; VAKANI T; BAITZ T; MACPHEE E; TURTON E; TURTON M; CHAN N; MISTERSKI J; RACO D; CURNEW G; FALLEN E; FINKELSTEIN L; GERSTEIN H; HARDMAN P; LAWAND S; LONN E; MAGI W; MCQUEEN M; PANJU A; PATTERSON R; SULLIVAN B; SULLIVAN H; SULLIVAN M; TAYLOR K; WORRON I; YUSUF S; CAMERON W; NOSEWORTHY C; HOULDEN R; LAVALLE T; FOWLIS R; JANZEN I; ARNOLD M; CANN M; CARROLL S; DUMARESQ S; EDMONDS M; FURLONG P; GEDDES C; GRAHAM E; HARRIS K; HRAMIAK I; KENNEDY R; KOSTUK W; KRUPA M; LENT B; LOVELL M; MACLEAN C; MASSEL D; MCMANUS R; MCSHERRY J; MUNOZ C; OCCHIPINTI J; OOSTERVELD L; PFLUGFELDER P; POWERS S; SOUTHERN R; SPENCE D; SQUIRES P; WETMORE S; WILLING J; WISENBERG G; WOLFE B; KANNAMPUZHA P; REBANE T; SLUZAR V; HESS A; CHAN Y; THOMSON D; BAIGRIE R; DUBBIN J; LIUNI C; TAN KW; BRANKSTON E; HEWSON P; HRYCYSHYN B; KAPUSTA W; KNOX L; LOCKNER C; WHITSITT P; BAIRD M; CONROY D; DAVIES RA; DAVIES RF; FRASER M; HAGAR S; HIERLIHY P; KEELY E; KHAN S; LAU DGW; MAROIS L; NEMETH K; REEVES E; TUREK M; VEXLER R; YOUNG D; KUMAR G; KURUVILLA G; KURUVILLA P; LOWE D; KWOK K; BLAKELY J; STYLING S; BOZEK B; CHARLES J; FELL D; FELL DA; GOODE E; GROSSMAN LD; MATTHEWS E; NITKIN R; RICCI J; SELBY A; SINGH N; SWAN J; EMMETT J; WEINGERT M; BAIGRIE R; GANJAVI F; HILL D; NAWAZ S; HESSIAN R; KWIATKOWSKI K; LAI C; MULAISHO C; OKEEFE H; SMITH H; WEEKS A; ANDREWS J; BARNIE A; DROBAC M; HACKER P; HANNA A; IWANOCHKO M; KENSHOLE A; LANGER A; LIU P; MACLEAN S; MOE G; SASSON Z; STERNBERG L; TRACHUK C; WALTERS J; ZINMAN B; CHEUNG M; CINA C; YAO L; MAN K; FULOP J; GLANZ A; SIBBICK M; CARTER P; OOSTERVELD L; HICKEY J; MCMILLIAN E; DION D; STHILAIRE R; COUTU D; DAMOURS G; STARRA R; BROOKS J; DECHAMPS P; KIWAN G; KOUZ S; LAFOREST M; REMILLARD C; BELLAMY D; BROSSOIT R; CARRIER S; HOUDE A; LABONTE I; BELANGER A; KANDALAFT N; QUENNEVILLE L; SANDI M; AUGER P; BILODEAU N; DELAGE F; DUMONT F; GIROUX R; LOISEL R; POIRIER C; SAULNIER D; CARMICHAEL P; LEMAY C; LENIS J; ARISJILWAN N; BEDARD H; CASAVANT C; CHIASSON J; DAGENAIS D; FITCHETT D; GOSSARD D; HALLE H; HAMEL N; JOYAL M; MAGNAN O; METHE M; PEDNEAULT L; PILON C; POISSON D; PRIMEAU L; RONDEAU C; ROY C; RUEL M; SERPA A; SESTIER F; SMILOVITCH M; THEROUX P; BEAUDOIN J; BOUDREAULT JR; DAMOURS D; DOUVILLE T; GIGUERE G; HOUDE G; LABBE R; LACHANCE S; LESSARD L; MERCIER G; NOEL HP; TALBOT P; TREMBLAY J; KARABATSOS A; MACLELLAN K; WILSON P; BOGATY P; LAFORGE D; LANGLAIS M; LEBLANC M; SAMSON M; TURCOTTE J; CAMPEAU J; DUPUIS R; LAUZON C; OUIMET F; PRUNEAU G; DESMARIS C; FRECHETTO I; GERVAIS P; BROPHY J; LEROUX S; BESTER S; MEUNIER L; SAYEED M; HART M; MOUMNE I; THOMASSE G; WALKER J; WALKER M; AHMED S; HABIB NM; HABIB NM; KUNY P; LOPEZ J; KLEIN W; GRISOLD M; HEYNDRICKX L; FIASSE A; DEGAUTE JP; MOCKEL J; DUPREZ D; CHAUDRON JM; BODSON A; KRZENTOWSKI G; BOLAND J; KOLENDORF K; WINTHER B; JUHL H; HAMALAINEN T; SIITONEN O; GIN H; RIGALLEAU V; HENSEN J; RIEL R; OEHMENBRITSCH R; SCHULZESCHLEPPINGHOFF B; HOPF R; MOLLER A; ROSAK C; WETZEL H; HASSLACHER C; MARTIN T; STEIN J; ERDMANN E; BOHM M; HARTMANN D; BREIDERT M; FRITZEN R; SCHERBAUM W; MANN J; MAUS J; SCHROEDER C; HENRICHS H; UNGER H; ICKENSTEIN G; KROMER E; RIEGGER G; SCHUNKERT H; BASAN B; HAMPEL R; CREAN P; GARADAH T; WHITE U; MARINI N; PACIARONI E; SACCOMANO G;
Indirizzi:
HAMILTON GEN HOSP,CANADIAN CARDIOVASC COLLABORAT,237 BARTON ST E HAMILTON ON L8L 2X2 CANADA HAMILTON GEN HOSP,CANADIAN CARDIOVASC COLLABORAT HAMILTON ON L8L 2X2 CANADA
Titolo Testata:
Canadian journal of cardiology
fascicolo: 2, volume: 12, anno: 1996,
pagine: 127 - 137
SICI:
0828-282X(1996)12:2<127:TH(OPE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-INFARCTION; E CONSUMPTION; DISEASE; MORTALITY; HYPERTENSION; CHOLESTEROL; LIPOPROTEIN; REGRESSION; ENALAPRIL; MEN;
Keywords:
ANGIOTENSIN-CONVERTING ENZYMES INHIBITORS; CARDIOVASCULAR PREVENTION; HOPE STUDY; RANDOMIZED TRIAL METHODOLOGY; VITAMIN-E ANTIOXIDANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
F. Mindlen et al., "THE HOPE (HEART OUTCOMES PREVENTION EVALUATION) STUDY - THE DESIGN OFA LARGE, SIMPLE RANDOMIZED TRIAL OF AN ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR (RAMIPRIL) AND VITAMIN-E IN PATIENTS AT HIGH-RISK OF CARDIOVASCULAR EVENTS", Canadian journal of cardiology, 12(2), 1996, pp. 127-137

Abstract

OBJECTIVE: To describe the design of the HOPE (Heart Outcomes Prevention Evaluation) Study. DESIGN: Description of the key design features of HOPE, a large, simple randomized trial of two widely applicable treatments - ramipril, an angiotensin-converting enzyme inhibitor; and vitamin E, a naturally occurring antioxidant vitamin - in the preventionof myocardial infarction, stroke or cardiovascular death. SETTING: Two-hundred and sixty-seven hospitals, physician offices and clinics in Canada, the United States, Mexico, Europe and South America. PATIENTS:Over 9000 women and men aged 55 years and above at high risk for cardiovascular events such as myocardial infarction and stroke were recruited over 18 months. INTERVENTIONS: A 2x2 factorial design with ramipril and vitamin E with follow-up for up to four years. CONCLUSIONS: HOPEwill be one of the largest trials of two new interventions to preventmyocardial infarction, stroke or cardiovascular death in high risk patients. The results of HOPE will have direct public health impact and are likely to be readily incorporated into clinical practice. Key design features of HOPE are inclusion of individuals at high risk of cardiovascular disease, inclusion of a substantial proportion of patients with diabetes (36%) and women (27%), and detailed substudies to providedata on mechanisms of benefit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:59:06