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Titolo:
THE DOPAMINE D-2 RECEPTOR (DRD2) GENE - A GENETIC RISK FACTOR IN SMOKING
Autore:
COMINGS DE; FERRY L; BRADSHAWROBINSON S; BURCHETTE R; CHIU C; MUHLEMAN D;
Indirizzi:
CITY HOPE NATL MED CTR DUARTE CA 91010 JERRY L PETTIS VET AFFAIRS HOSP LOMA LINDA CA 00000
Titolo Testata:
Pharmacogenetics
fascicolo: 1, volume: 6, anno: 1996,
pagine: 73 - 79
SICI:
0960-314X(1996)6:1<73:TDDR(G>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLELIC ASSOCIATION; SUBSTANCE USE; ALCOHOLISM; LOCUS; DEPENDENCE; SCHEDULE; SYSTEM; REWARD; DRUGS; BRAIN;
Keywords:
NICOTINE; SMOKING; DOPAMINE; DRD2; RECEPTORS; ADDICTION; TOBACCO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Comings et al., "THE DOPAMINE D-2 RECEPTOR (DRD2) GENE - A GENETIC RISK FACTOR IN SMOKING", Pharmacogenetics, 6(1), 1996, pp. 73-79

Abstract

Of a group of 312 non-Hispanic Caucasians who smoked at least one pack per day, had unsuccessfully attempted to stop smoking, and were freeof alcohol or other drug dependence, 48.7% carried the A1 allele of the DRD2 gene. This was significantly greater than the 25.9% prevalencein the 714 known non-Hispanic Caucasian controls without alcohol or drug abuse, p < 10(-8), and significantly greater than in a smaller setof our study controls. There was a significant, inverse relationship between the prevalence of the D(2)A1 allele and the age of onset of smoking, p = 0.02, and the maximum duration of time the smokers had beenable to quit smoking on their own, p = 0.02. These results suggest the DRD2 gene is one of a multifactorial set of risk factors associated with smoking.

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Documento generato il 02/12/20 alle ore 05:30:36