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Titolo:
DEPLETION OF VASOACTIVE-INTESTINAL-PEPTIDE AND SUBSTANCE-P IN PAROTID-GLANDS OF ATROPINIZED RATS DURING REFLEX SECRETION
Autore:
ASZTELY A; EKMAN R; TOBIN G; EKSTROM J;
Indirizzi:
GOTHENBURG UNIV,DEPT PHARMACOL,INST PHYSIOL & PHARMACOL GOTHENBURG SWEDEN GOTHENBURG UNIV,DEPT PHARMACOL,INST PHYSIOL & PHARMACOL GOTHENBURG SWEDEN GOTHENBURG UNIV,DEPT PSYCHIAT & NEUROCHEM GOTHENBURG SWEDEN
Titolo Testata:
Experimental physiology
fascicolo: 2, volume: 81, anno: 1996,
pagine: 297 - 303
SICI:
0958-0670(1996)81:2<297:DOVASI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; SALIVARY-GLANDS; SUPER-SENSITIVITY; EVOKED SECRETION; STIMULATION; NERVE; DENERVATION; INNERVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A. Asztely et al., "DEPLETION OF VASOACTIVE-INTESTINAL-PEPTIDE AND SUBSTANCE-P IN PAROTID-GLANDS OF ATROPINIZED RATS DURING REFLEX SECRETION", Experimental physiology, 81(2), 1996, pp. 297-303

Abstract

Rats previously starved for 30 h were offered hard chow over a periodof 80 min, and the effect of eating on the parotid gland content of vasoactive intestinal peptide (VIP), substance P and neuropeptide Y (NPY) was examined. In rats pretreated with I.P. atropine and alpha- and beta-adrenoceptor blocking agents, the total amounts of VIP and substance P were reduced after feeding by 23 and 42%, respectively; in contrast the NPY content was not significantly affected. Similarly, in animals given atropine alone the VIP content was reduced by 25 % and substance P by 40 % after feeding. In the absence of autonomic receptor blockade, there was no loss of parotid neuropeptide content in response to feeding. Neither an intact sympathetic innervation nor a capsaicin-sensitive sensory innervation was a prerequisite for depletion of parotid neuropeptides in the presence of atropine and adrenoceptor blockers. The observed decrease in neuropeptide content is thought to reflect an imbalance between peptide release from nerve terminals and their replenishment by axonal transport, this imbalance resulting from the unusually high demands on the parasympathetic non-adrenergic, non-cholinergic (NANC) mechanism. Under normal conditions salivary peptidergic mechanisms are spared as seen in the absence of autonomic receptor blockade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 09:39:38