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Titolo:
ANTIGEN-INDUCED ANAPHYLACTIC DEATH IN MICE
Autore:
LEI HY; LEE SH; LEIR SH;
Indirizzi:
NATL CHENG KUNG UNIV,DEPT MICROBIOL,COLL MED TAINAN TAIWAN NATL CHENG KUNG UNIV,DEPT IMMUNOL,COLL MED TAINAN TAIWAN
Titolo Testata:
International archives of allergy and immunology
fascicolo: 4, volume: 109, anno: 1996,
pagine: 407 - 412
SICI:
1018-2438(1996)109:4<407:AADIM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PASSIVE CUTANEOUS ANAPHYLAXIS; CELL-DEFICIENT STRAIN; B SURFACE-ANTIGEN; PAF-ACETHER; GUINEA-PIG; WBB6F1 MOUSE; SHOCK; HYPERSENSITIVITY; ANTIBODIES;
Keywords:
ANAPHYLAXIS; EARLY-TYPE HYPERSENSITIVITY; VASOPERMEABILITY; FATAL BLOOD VOLUME LOSS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
H.Y. Lei et al., "ANTIGEN-INDUCED ANAPHYLACTIC DEATH IN MICE", International archives of allergy and immunology, 109(4), 1996, pp. 407-412

Abstract

Intravenous injection of bovine serum albumin (BSA) into the BSA/CFA-primed ICR mice specifically induced anaphylactic death within 1 h. The anaphylactic death could not be induced until day 8 after sensitization, and sensitization subsisted for more than 3 months. The response was dose dependent; mice challenged with BSA doses higher or equivalent to 25 mu g developed anaphylactic death. The intravenous route was more effective than the intraperitoneal one, while subcutaneous injection was ineffective. Antigen in any of complete Freund's adjuvant, incomplete Freund's adjuvant or aluminum hydroxide could sensitize the mice to develop anaphylactic death. The combination of antigen and the mouse strain or the gender of the mouse determined the susceptibility ofthe anaphylactic death. AKR, B10.BR, as well as ICR, strains were susceptible. Antigen of HoGG induced a higher mortality rate than that ofGAT or lysozyme. Male mice were more susceptible than female ones. The BSA-induced anaphylactic death could be prevented by pretreating ICRmice with cyproheptadine (histamine and serotonin antagonist) or diphenhydramine (histamine antagonist) and ketanserin (serotonin antagonist). Intravenous injection of saline during anaphylaxis also protected the mice from death. Furthermore, immune serum could transfer the anaphylactic death, and heat (56 degrees C, 4 h) did not destroy its activity. The primary IgG subclass induced by GAT, HoGG or lysozyme was IgG1. There was no qualitative difference in the IgG subclass induced in different strains by different antigens. The IgE class of antibodies was not detectable. These results suggest that there is a non-IgE-mediated anaphylactic death which involves the release of histamine and serotonin that cause the increase of vasopermeability and fatal blood volume loss.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 21:32:45