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Titolo:
DIFFERENT HLA-DQ ARE POSITIVELY AND NEGATIVELY ASSOCIATED IN SWEDISH PATIENTS WITH MYASTHENIA-GRAVIS
Autore:
HJELMSTROM P; GISCOMBE R; LEFVERT AK; PIRSKANEN R; KOCKUM I; LANDINOLSSON M; SANJEEVI CB;
Indirizzi:
KAROLINSKA INST,KAROLINSKA HOSP,DEPT MOLEC MED,LAB MOLEC IMMUNOL,M3 00 S-17176 STOCKHOLM SWEDEN KAROLINSKA INST,KAROLINSKA HOSP,DEPT MOLEC MED,LAB MOLEC IMMUNOL S-17176 STOCKHOLM SWEDEN
Titolo Testata:
Autoimmunity
fascicolo: 1, volume: 22, anno: 1995,
pagine: 59 - 65
SICI:
0891-6934(1995)22:1<59:DHAPAN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RECEPTOR; MULTIPLE-SCLEROSIS; ANTIGENS; GENES; SUSCEPTIBILITY; DISEASE; POLYMORPHISM; HAPLOTYPES; CHINESE; ALPHA;
Keywords:
MYASTHENIA GRAVIS; HLA-DQ; MAJOR HISTOCOMPATIBILITY COMPLEX; PCR-SSO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
P. Hjelmstrom et al., "DIFFERENT HLA-DQ ARE POSITIVELY AND NEGATIVELY ASSOCIATED IN SWEDISH PATIENTS WITH MYASTHENIA-GRAVIS", Autoimmunity, 22(1), 1995, pp. 59-65

Abstract

The aim of this study was to determine the association between HLA-DQand myasthenia gravis (MG) in 79 Swedish patients and 155 unrelated population based controls. HLA genotyping was done using polymerase chain reaction combined with sequence specific oligonucleotide probes, The DQB allele, DQB10201 was positively associated with MG, 39/79 (49%)patients and 43/152 (28%) controls (OR 2.47, Pc = 0.037). DQB1+0201 was observed more frequently in patients with an early onset of disease, below 30 years (Pc = 0.033). A negative association was found for DQA10103, 7/78 (9%) patients and 38/154 (25%) controls (OR 0.30, Pc = 0.037). DQA10501-DQB1*0201 and DQA1*0201-DQB1*0201 together was significantly increased in patients when compared to controls (OR 2.68; Pc =0.019). In conclusion, two different DQ2 haplotypes (DQA10501-DQB1*0201 and DQA10201-DQB1*0201) were positively and the DQA1*0103 allele was negatively associated with MG. Susceptibility and resistance to MGin Swedish patients is mediated by HLA-DQ.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:20:52