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Titolo:
EXPRESSION OF ATTACHING EFFACING ACTIVITY BY ENTEROPATHOGENIC ESCHERICHIA-COLI DEPENDS ON GROWTH-PHASE, TEMPERATURE, AND PROTEIN-SYNTHESIS UPON CONTACT WITH EPITHELIAL-CELLS
Autore:
ROSENSHINE I; RUSCHKOWSKI S; FINLAY BB;
Indirizzi:
HEBREW UNIV JERUSALEM,FAC MED,DEPT BIOTECHNOL & MOL GENET,POB 12272 IL-91120 JERUSALEM ISRAEL UNIV BRITISH COLUMBIA,BIOTECHNOL LAB VANCOUVER BC V6T 1Z3 CANADA
Titolo Testata:
Infection and immunity
fascicolo: 3, volume: 64, anno: 1996,
pagine: 966 - 973
SICI:
0019-9567(1996)64:3<966:EOAEAB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-CULTURE CELLS; HEP-2 CELLS; LOCALIZED ADHERENCE; HELA-CELLS; PHOSPHORYLATION; LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
I. Rosenshine et al., "EXPRESSION OF ATTACHING EFFACING ACTIVITY BY ENTEROPATHOGENIC ESCHERICHIA-COLI DEPENDS ON GROWTH-PHASE, TEMPERATURE, AND PROTEIN-SYNTHESIS UPON CONTACT WITH EPITHELIAL-CELLS", Infection and immunity, 64(3), 1996, pp. 966-973

Abstract

Enteropathogenic Escherichia coli (EPEC) induces tyrosine phosphorylation of a 90-kDa protein (Hp90) in infected epithelial cells. This in turn facilitates intimate binding of EPEC via the outer membrane protein intimin, effacement of host cell microvilli, cytoskeletal rearrangement, and bacterial uptake. This phenotype has been commonly referred to as attaching/effacing (A/E). The ability of EPEC to induce A/E lesions was de-pendent on bacterial growth phase acid temperature. Early-logarithmic-phase EPEC grown at 37 degrees C elicits strong A/E activity within minutes after infection of HeLa epithelial cells, EPEC de nova protein synthesis du:ring the first minutes of interaction with the host cell was required to elicit A/E lesions, However, once formed, bacterial viability was not needed to maintain A/E lesions, The type of growth media and partial O-2 pressure Level do nut seem to affect the ability of EPEC to cause A/E lesions, The results indicates that the A/E activity of EPEC is tightly regulated by environmental and host factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 09:01:29