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Titolo:
INHIBITION OF HIV-1 REPLICATION IN LYMPHOCYTES BY MUTANTS OF THE REV COFACTOR EIF-5A
Autore:
BEVEC D; JAKSCHE H; OFT M; WOHL T; HIMMELSPACH M; PACHER A; SCHEBESTA M; KOETTNITZ K; DOBROVNIK M; CSONGA R; LOTTSPEICH F; HAUBER J;
Indirizzi:
SANDOZ GMBH,RES INST,DEPT IMMUNODERMATOL A-1235 VIENNA AUSTRIA SANDOZ GMBH,RES INST,DEPT IMMUNODERMATOL A-1235 VIENNA AUSTRIA RES INST MOLEC PATHOL A-1030 VIENNA AUSTRIA MAX PLANCK INST BIOCHEM D-82152 MARTINSRIED GERMANY
Titolo Testata:
Science
fascicolo: 5257, volume: 271, anno: 1996,
pagine: 1858 - 1860
SICI:
0036-8075(1996)271:5257<1858:IOHRIL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; EUKARYOTIC INITIATION FACTOR-5A; GENE-EXPRESSION REQUIRES; HUMAN T-CELLS; TRANS-ACTIVATOR; RESPONSIVE ELEMENT; REGULATORY GENES; CARBOXY-TERMINUS; TARGET SEQUENCE; MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
D. Bevec et al., "INHIBITION OF HIV-1 REPLICATION IN LYMPHOCYTES BY MUTANTS OF THE REV COFACTOR EIF-5A", Science, 271(5257), 1996, pp. 1858-1860

Abstract

Eukaryotic initiation factor 5A (eIF-5A) is a cellular cofactor required for the function of the human immunodeficiency virus type-1 (HIV-1) Rev trans-activator protein. The majority of a set of eIF-5A mutantsdid not support growth of yeast cells having an inactivated genomic copy of eIF-5A, indicating that the introduced mutation eliminated eIF-5A activity. Two nonfunctional mutants, eIF-5AM13 and eIF-5AM14, retained their binding capacity for the HIV-1 Rev response element:Rev complex. Both mutants were constitutively expressed in human T cells. Whenthese T cells were infected with replication-competent HIV-1, virus replication was inhibited. The eIF-5AM13 and eIF-5AM14 proteins blockedRev trans-activation and Rev-mediated nuclear export.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:55:22