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Titolo:
IN-VIVO COMPARTMENTAL METABOLISM OF C-13 DOCOSAHEXAENOIC ACID, STUD LED BY GAS-CHROMATOGRAPHY COMBUSTION ISOTOPE RATIO MASS-SPECTROMETRY
Autore:
CROSET M; BROSSARD N; PACHIAUDI C; NORMAND S; LECERF J; CHIROUZE V; RIOU JP; TAYOT JL; LAGARDE M;
Indirizzi:
INSA,INSERM U352 VILLEURBANNE FRANCE FAC MED ALEXIS CARREL,INSERM U197 F-69372 LYON FRANCE IMEDEX CHAPONOST FRANCE
Titolo Testata:
Lipids
, volume: 31, anno: 1996, supplemento:, S
pagine: 109 - 115
SICI:
0024-4201(1996)31:<109:ICMOCD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-3 FATTY-ACIDS; LIPOPROTEIN METABOLISM; HEPATIC SECRETION; RETINA; BRAIN; PHOSPHATIDYLETHANOLAMINE; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPIDS; TRANSPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Croset et al., "IN-VIVO COMPARTMENTAL METABOLISM OF C-13 DOCOSAHEXAENOIC ACID, STUD LED BY GAS-CHROMATOGRAPHY COMBUSTION ISOTOPE RATIO MASS-SPECTROMETRY", Lipids, 31, 1996, pp. 109-115

Abstract

The exchange of docosahexaenoic acid (22:6n-3) within lipid pools in rat and human has been followed as a function of time after the ingestion of triglycerides (TG) containing 22:6n-3 labeled with C-13 (C-13 22:6n-3). The C-13 abundance in the fatty acid was measured by gas-chromatography-combustion isotope ratio mass spectrometry which allowed the detection of 0.001 atom C-13 percent C-12. Th, C-13 22:6n-3 appearance was rapid in the TC of very low density lipoprotein plus chylomicron fraction, in which the maximal labeling was observed at 3 and 2 h after ingestion in rat and human, respectively. Concomitant with the TC utilization of this fraction by lipoprotein lipase from tissues, unesterified C-13 22:6n-3 appeared in the plasma albumin. C-13 22:6n-3 bound to albumin was mostly present in unesterified form before 12 h post-ingestion while after that period, lysophosphatidylcholine (lysoPC) bound to albumin carried higher C-13 22:6n-3 concentrations. These lyse-PC were mostly from hepatic origin and might represent a potential source of 22:6n-3 redistribution to tissues. The C-13 22:6n-3 uptake intorat brain PC and phosphatidylethanolamine was still increasing when the concentration of plasma unesterified C-13 22:6n-3 had already dropped to a minimal plateau value and during the period of maximal plasma circulation of C-13 22:6n-3-lysoPC bound to albumin. In contrast, the uptake of C-13 22:6n-3 into blood platelet PC occurred during the phase of important circulation of C-13-22:6n-3 bound to albumin, suggesting the in vivo efficiency of the Lands pathway for this fatty acid. It is concluded that C-13 22:6n-3 esterified in TG is rapidly absorbed and redistributed within plasma lipoproteins and that its redistributionwithin the two lipid species bound to;albumin might influence its uptake by platelets and rat brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 03:48:42