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Titolo:
ON THE CYTOTOXICITY OF IRRADIATED MEDIA - TO WHAT EXTENT ARE STABLE PRODUCTS OF RADICAL-CHAIN REACTIONS IN PHYSIOLOGICAL SALINE RESPONSIBLEFOR CELL-DEATH
Autore:
SARAN M; BERTRAM H; BORS W; CZAPSKI G;
Indirizzi:
GSF,RES CTR,INST STRAHLENBIOL D-85758 OBERSCHLEISSHEIM GERMANY HEBREW UNIV JERUSALEM,DEPT PHYS CHEM JERUSALEM ISRAEL
Titolo Testata:
International journal of radiation biology
fascicolo: 3, volume: 64, anno: 1993,
pagine: 311 - 318
SICI:
0955-3002(1993)64:3<311:OTCOIM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHAGOCYTES; NO2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. Saran et al., "ON THE CYTOTOXICITY OF IRRADIATED MEDIA - TO WHAT EXTENT ARE STABLE PRODUCTS OF RADICAL-CHAIN REACTIONS IN PHYSIOLOGICAL SALINE RESPONSIBLEFOR CELL-DEATH", International journal of radiation biology, 64(3), 1993, pp. 311-318

Abstract

In a previous publication (Czapski et al. 1992) we reported that HOClaccounts for the toxicity of irradiated phosphate-buffered saline towards Escherichia coli bacterial cells. We have now investigated the respective toxicities towards lambda phage and mammalian cells. For phage, as with bacteria, cytotoxicity of the irradiated media seems to derive from HOCl without detectable contribution of H2O2. Mammalian cells(V79 CHO), in contrast, are more sensitive to H2O2 than to HOCl. Bothagents, however, are not able to account quantitatively for the toxicity of irradiated solutions towards V79 cells; a hitherto unidentifiedchlorine/oxygen derivative-being formed in the sub-micromolar concentration range-is suggested to be responsible for toxicity in the case of eukaryotes.

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Documento generato il 26/09/20 alle ore 05:40:09