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Titolo:
AGE-DEPENDENT INFLUENCE OF OCTREOTIDE ON STIMULATED PANCREATIC GROWTHIN THE POSTNATAL-PERIOD OF RATS
Autore:
KISFALVI K; FRIESS H; BUCHLER MW; TULASSAY Z; VARGA C; PAPP M;
Indirizzi:
UNIV BERN,INSELSPITAL,DEPT VISCERAL & TRANSPLANTAT SURG CH-3010 BERN SWITZERLAND UNIV BERN,INSELSPITAL,DEPT VISCERAL & TRANSPLANTAT SURG CH-3010 BERN SWITZERLAND
Titolo Testata:
European journal of gastroenterology & hepatology
fascicolo: 1, volume: 8, anno: 1996,
pagine: 69 - 74
SICI:
0954-691X(1996)8:1<69:AIOOOS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CCK-ANTAGONIST L-364,718; TRYPSIN-INHIBITOR; SOMATOSTATIN ANALOG; EXOCRINE PANCREAS; SUCKLING RATS; FACTOR-I; PLASMA CHOLECYSTOKININ; CERULEIN; SECRETION; RECEPTOR;
Keywords:
CERULEIN; CAMOSTATE; CCK-8; GROWTH HORMONE; LONG-ACTING SOMATOSTATIN; PANCREATIC GROWTH; PREWEANING RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
K. Kisfalvi et al., "AGE-DEPENDENT INFLUENCE OF OCTREOTIDE ON STIMULATED PANCREATIC GROWTHIN THE POSTNATAL-PERIOD OF RATS", European journal of gastroenterology & hepatology, 8(1), 1996, pp. 69-74

Abstract

Objective: To investigate the effect of long-acting octreotide (SMS 201-995) on the plasma growth hormone level in preweaning rats and to study the growth and composition of the exocrine pancreas in these ratsafter stimulation by caerulein- and camostate-induced endogenous cholecystokinin (CCK). Methods: Wistar rats of both sexes were treated as littermate pairs in two periods of postnatal age, from days 1 to 11 and from days 11 to 21. To stimulate pancreatic growth, caerulein (3 mu g/kg subcutaneously three times daily) was given from days 1 to 11, and oral camostate (200 mg/kg given once daily) or CCK-8 (10 mu g/kg subcutaneously three times daily) was administered from days 11 to 21. Octreotide (6 or 15 mu g/kg subcutaneously twice daily) was administeredalone or in combination with caerulein or camostate. The rats were exsanguinated on days 11 or 21, and each pancreas was removed, weighed and analysed. Results: Caerulein stimulated pancreatic growth and raised the trypsin concentration; camostate induced pancreatic hypertrophy and hyperplasia. By day 11, octreotide had decreased the plasma growthhormone level and the basal pancreatic trypsin concentration and content. Given in combination with caerulein, octreotide reduced the growth hormone level and the stimulated trypsin and DNA contents. By day 21, rats treated with octreotide in the camostate group showed a reducedbasal pancreatic trypsin concentration and a decreased basal trypsin content (although the changes were not significant). Plasma growth hormone levels were not significantly reduced. Conclusion: The antitrophic pancreatic action of octreotide and its plasma growth hormone-lowering effect were shown in rats during the first 10 days after birth. These effects were less notable from days 11 to 21, a period when CCK receptors increase in number and components of the stimulus-secretion mechanism are mature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:18:02