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Titolo:
ALTERNATIVELY SPLICED ISOFORMS OF THE NMDARI RECEPTOR SUBUNIT
Autore:
ZUKIN RS; BENNETT MVL;
Indirizzi:
ALBERT EINSTEIN COLL MED,DEPT NEUROSCI BRONX NY 10461
Titolo Testata:
Trends in neurosciences
fascicolo: 7, volume: 18, anno: 1995,
pagine: 306 - 313
SICI:
0166-2236(1995)18:7<306:ASIOTN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; POLYAMINES; VARIANTS; CLONING;
Tipo documento:
Review
Natura:
Periodico
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Zukin e M.V.L. Bennett, "ALTERNATIVELY SPLICED ISOFORMS OF THE NMDARI RECEPTOR SUBUNIT", Trends in neurosciences, 18(7), 1995, pp. 306-313

Abstract

Molecularly diverse forms of the NMDA-receptor subunit NR I are formed by alternative RNA splicing. Differential splicing of three exons generates as many as eight NR1 splice variants, seven of which have beenidentified in cDNA libraries. The alternatively spliced exons encode a 21 amino acid sequence in the N-terminus domain (termed N1), and adjacent sequences of 37 and 38 amino acids in the C-terminus domain (termed C1 and C2, respectively). Splicing out the exon segment that encodes the C2 cassette removes the first stop codon, resulting in a new open reading frame that encodes an unrelated sequence of 22 amino acids (C2') before a second stop codon is reached. Differential RNA splicingalters the structural, physiological and pharmacological properties of receptors that comprise NR1 subunits. Diversity of NMDA receptors isalso caused by differential association with members of the NR1 gene family. The finding of cell-specific expression and developmental regulation of NR1 splice variants, and of the NR2 subunits, provides an explanation for the diversity of properties of NMDA receptors in different neuronal populations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:56:16