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Titolo:
RELATIONSHIP BETWEEN DRUG PERCOLATION-THRESHOLD AND PARTICLE-SIZE IN MATRIX TABLETS
Autore:
CARABALLO I; MILLAN M; RABASCO AM;
Indirizzi:
UNIV SEVILLE,FAC PHARM,DEPT PHARM & PHARMACEUT TECHNOL E-41012 SEVILLE SPAIN
Titolo Testata:
Pharmaceutical research
fascicolo: 3, volume: 13, anno: 1996,
pagine: 387 - 390
SICI:
0724-8741(1996)13:3<387:RBDPAP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORRELATED PERCOLATION; SYSTEMS; BEHAVIOR;
Keywords:
PERCOLATION THEORY; PERCOLATION THRESHOLD; INERT MATRIX TABLETS; PARTICLE SIZE; CONTROLLED RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
I. Caraballo et al., "RELATIONSHIP BETWEEN DRUG PERCOLATION-THRESHOLD AND PARTICLE-SIZE IN MATRIX TABLETS", Pharmaceutical research, 13(3), 1996, pp. 387-390

Abstract

Purpose. Since a previous qualitative study carried out by us showed the existence of an important influence of the particle size on the percolation thresholds and taking into account that the existing theoretical models can only provide qualitative explanation to this influence, the purpose of this work is to carry out the first quantitative study of the influence of the particle size over the drug percolation thresholds. Methods. Matrix tablets have been elaborated using potassium chloride as drug model and Eudragit RS-PM as matrix forming material. Five different KCI particle size fractions have been employed whereas the Eudragit(R) RS-PM particle size was kept constant. In-vitro releaseassays were carried out for all the elaborated lots. The drug percolation thresholds were estimated following the method proposed by Bonny and Leuenberger. Results. A linear relationship has been found betweenthe drug particle size and the corresponding drug percolation threshold. Conclusions. This finding confirms the results previously obtainedin our qualitative study and has important repercussions in the design of pharmaceutical solid dosage forms. If this linear behaviour is general, the percolation threshold can soon become a useful preformulation parameter.

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Documento generato il 02/12/20 alle ore 08:12:22