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Titolo:
DETAILED DELETION MAPPING IN SQUAMOUS-CELL CARCINOMAS OF THE ESOPHAGUS NARROWS A REGION CONTAINING A PUTATIVE TUMOR-SUPPRESSOR GENE TO ABOUT 200 KILOBASES ON DISTAL CHROMOSOME 9Q(1)
Autore:
MIURA K; SUZUKI K; TOKINO T; ISOMURA M; INAZAWA J; MATSUNO S; NAKAMURA Y;
Indirizzi:
UNIV TOKYO,INST MED SCI,LAB MOL MED,MINATO KU,4-6-1 SHIROKANEDAI TOKYO 108 JAPAN UNIV TOKYO,INST MED SCI,LAB MOL MED,MINATO KU TOKYO 108 JAPAN KYOTO PREFECTURAL UNIV MED,DEPT HYG,KAMIKYO KU KYOTO 602 JAPAN TOHOKU UNIV,SCH MED,DEPT SURG 1,AOBA KU SENDAI MIYAGI 98077 JAPAN
Titolo Testata:
Cancer research
fascicolo: 7, volume: 56, anno: 1996,
pagine: 1629 - 1634
SICI:
0008-5472(1996)56:7<1629:DDMISC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLADDER-CANCER; HETEROZYGOSITY; AMPLIFICATION; LOCI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K. Miura et al., "DETAILED DELETION MAPPING IN SQUAMOUS-CELL CARCINOMAS OF THE ESOPHAGUS NARROWS A REGION CONTAINING A PUTATIVE TUMOR-SUPPRESSOR GENE TO ABOUT 200 KILOBASES ON DISTAL CHROMOSOME 9Q(1)", Cancer research, 56(7), 1996, pp. 1629-1634

Abstract

We previously reported definition of a region containing a putative tumor suppressor gene for esophageal squamous cell carcinoma within an similar to 4-cM genomic segment at 9q31-q32. We have investigated thisregion further using six new microsatellite markers isolated from yeast artificial chromosome clones covering the deleted region and have narrowly defined the commonly deleted region to a segment between two loci, KM9.1 and D9S177, On the basis of the contig map of cosmid and yeast artificial chromosome clones, we estimate the physical size of theregion of interest to be about 200 kb, Because the distal 9q region also has been implicated as the site of a tumor suppressor gene(s) related to squamous cell carcinomas of other tissues, our map provides useful information for attempts to identify a common gene for carcinomas of this cell type.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 07:05:26