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Titolo:
LAMOTRIGINE POTENTIATES THE ANTISEIZURE ACTIVITY OF SOME ANTICONVULSANTS IN DBA 2 MICE/
Autore:
DESARRO G; NAVA F; AGUGLIA U; DESARRO A;
Indirizzi:
POLICLIN MATER DOMINI,SCH MED CATANZARO,DEPT EXPT & CLIN MED,CHAIR PHARMACOL,VIA T CAMPANELLA I-88100 CATANZARO ITALY UNIV REGGIO CALABRIA,SCH MED CATANZARO,INST NEUROL I-89100 REGGIO CALABRIA ITALY UNIV MESSINA,SCH MED,INST PHARMACOL,CHAIR CHEMOTHERAPY MESSINA ITALY
Titolo Testata:
Neuropharmacology
fascicolo: 2, volume: 35, anno: 1996,
pagine: 153 - 158
SICI:
0028-3908(1996)35:2<153:LPTAAO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; EPILEPSY-PRONE RATS; NMDA ANTAGONISTS; REFLEX EPILEPSY; CPPENE; NBQX; PHARMACOKINETICS; GYKI-52466; MODEL; DRUG;
Keywords:
EPILEPSY; LAMOTRIGINE; CARBAMAZEPINE; PHENOBARBITAL; PHENYTOIN; VALPROATE; ANTICONVULSANTS; AUDIOGENIC SEIZURES; DBA/2 MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
G. Desarro et al., "LAMOTRIGINE POTENTIATES THE ANTISEIZURE ACTIVITY OF SOME ANTICONVULSANTS IN DBA 2 MICE/", Neuropharmacology, 35(2), 1996, pp. 153-158

Abstract

Lamotrigine [0.5-10 mg/kg, intraperitoneally (i.p.)] was able to antagonize the audiogenic seizures in DBA/2 mice in a dose-dependent manner. Lamotrigine at doses of 0.5 and 1.25 mg/kg i.p., which per se did not significantly affect the occurrence of audiogenic seizures in DBA/2mice, markedly potentiated the anticonvulsant activity of carbamazepine, diazepam, phenytoin, phenobarbital and valproate against sound induced seizures in DBA/2 mice. The degree of potentiation by lamotriginewas greatest for diazepam and valproate, lower for phenobarbital, andleast for phenytoin and carbamazepine. The increase in anticonvulsantactivity was associated with a comparable increase in motor impairment. However, the therapeutic index of combined treatment of diazepam + lamotrigine or valproate + lamotrigine was more favourable than the diazepam + saline or valproate + saline treatment. Since lamotrigine didnot significantly influence the plasma levels of the anticonvulsant drugs studied we might suggest that pharmacokinetic interactions, in terms of total plasma levels, are not probable. However, the possibilitythat lamotrigine alters protein binding and increases the relative free vs protein bound ratio may not be excluded. Lamotrigine did not significantly affect the hypothermic effects of the anticonvulsant compounds studied. Lamotrigine showed an additive effect when administered in combination with some classical anticonvulsants, most notably valproate and diazepam.

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Documento generato il 02/04/20 alle ore 18:46:55