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Titolo:
CHRONIC NICOTINE TREATMENT UP-REGULATES MUSCARINIC M(1)-RECEPTORS IN THE RAT STOMACH
Autore:
OGLE CW; GLAVIN GB;
Indirizzi:
UNIV HONG KONG,FAC MED,SCH POSTGRAD MED EDUC & TRAINING,1-F PATRICK MANSON BLDG,S WING HONG KONG HONG KONG UNIV MANITOBA,FAC MED,DEPT PHARMACOL WINNIPEG MB R3T 2N2 CANADA UNIV MANITOBA,FAC MED,DEPT THERAPEUT & SURG WINNIPEG MB R3T 2N2 CANADA
Titolo Testata:
Medical science research
fascicolo: 2, volume: 24, anno: 1996,
pagine: 83 - 84
SICI:
0269-8951(1996)24:2<83:CNTUMM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ULCERATION; STRESS; STIMULATION; RECEPTORS;
Keywords:
NICOTINE; [H-3] PIRENZEPINE; MUSCARINIC M(1) RECEPTOR UP-REGULATION; STOMACH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
C.W. Ogle e G.B. Glavin, "CHRONIC NICOTINE TREATMENT UP-REGULATES MUSCARINIC M(1)-RECEPTORS IN THE RAT STOMACH", Medical science research, 24(2), 1996, pp. 83-84

Abstract

This study examines the hypothesis that gastric muscarinic receptor supersensitivity which follows partial vagal ganglion block by chronic nicotine administration, and which accounts for the observed time- anddose-dependent worsening effect of the alkaloid on cold-restraint stress-induced gastric ulcers in rats, could be due to muscarinic receptor upregulation. Samples of homogenised gastric glandular mucosae of rats given 0, 5 or 50 mu g nicotine mL(-1) drinking water for 10 days were tested for muscarinic receptor activity using [H-3] pirenzepine radioligand binding. Radioactivity in the filtered fraction was measured,and specific binding was calculated from the difference between totalbinding and binding in the presence of atropine. Binding capacity (B-max) was dose-dependently increased in the two nicotine-treated groups, but receptor affinity (K-D) was unchanged. These novel findings indicate that gastric muscarinic receptor supersensitivity consequent to chronic nicotine treatment is largely due to gastric M(1)-receptor upregulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/10/20 alle ore 03:31:31