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Titolo:
COMPARATIVE EFFECTS OF PACAP AND VIP ON PANCREATIC ENDOCRINE SECRETIONS AND VASCULAR-RESISTANCE IN RAT
Autore:
BERTRAND G; PUECH R; MAISONNASSE Y; BOCKAERT J; LOUBATIERESMARIANI MM;
Indirizzi:
CTR CNRS,INSERM PHARMACOL ENDOCRINOL,UPR 9023,RUE CARDONILLE F-34094 MONTPELLIER 5 FRANCE FAC MED,INST BIOL,PHARMACOL LAB F-34060 MONTPELLIER FRANCE
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 117, anno: 1996,
pagine: 764 - 770
SICI:
0007-1188(1996)117:4<764:CEOPAV>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLASE-ACTIVATING POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE; ADENYLATE-CYCLASE; GLUCAGON-SECRETION; RECEPTOR-BINDING; PITUITARY; INSULIN; PEPTIDE; RESPONSES; SYSTEM;
Keywords:
PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP); VASOACTIVE INTESTINAL PEPTIDE (VIP); SECRETIN; INSULIN; SECRETION; GLUCAGON SECRETION; VESSEL; RAT PANCREAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
G. Bertrand et al., "COMPARATIVE EFFECTS OF PACAP AND VIP ON PANCREATIC ENDOCRINE SECRETIONS AND VASCULAR-RESISTANCE IN RAT", British Journal of Pharmacology, 117(4), 1996, pp. 764-770

Abstract

1 The effects of pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal peptide (VIP) and secretin on pancreaticendocrine secretions and vascular resistance were investigated and compared in the isolated perfused pancreas of the rat. The PACAP/VIP receptor types involved have been characterized. 2 On insulin secretion, in the range 10(-11) to 10(-8) M, PACAP and VIP elicited a concentration-dependent biphasic response from pancreas perfused with 8.3 mM glucose; the peptides were equipotent. In contrast, secretin was ineffective in the range 10(-11) to 10(-9) M; at 10(-8) and 10(-7) M, it induced only low and transient insulin responses. On the other hand, the peptides did not modify the basal insulin release in the presence of a non stimulating glucose concentration (2.8 mM). 3 On glucagon secretion,PACAP and VIP (10(-11) to 10(-8) M) but also secretin (10(-9) to 10(-7) M) caused a concentration-dependent peak shaped response from pancreas perfused with 2.8 mM glucose; PACAP and VIP were equipotent and 20times more potent than secretin. On the other hand, the peptides did not affect the glucagon release in the presence of 8.3 mM glucose. 4 On pancreatic vessels, in the range 10(-11) to 10(-9) M, the three peptides were equipotent in inducing a concentration-dependent sustained increase in pancreatic flow rate. On the other hand, at the high concentration of 10(-7) M PACAP but not VIP provoked a transient decrease offlow rate. 5 This study provides evidence for PACAP/VIP type II receptors mediating insulin and glucagon secretion as well as vasodilatation in rat pancreas. In addition, the different efficacies of secretin suggest that these effects are mediated by different PACAP/VIP type II receptor subtypes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:29:50