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Titolo:
DOPAMINE-DERIVED ENDOGENOUS THYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE, N-METHYL-(R)-SALSOLINOL, INDUCED PARKINSONISM IN RAT - BIOCHEMICAL, PATHOLOGICAL AND BEHAVIORAL-STUDIES
Autore:
NAOI M; MARUYAMA W; DOSTERT P; HASHIZUME Y; NAKAHARA D; TAKAHASHI T; OTA M;
Indirizzi:
NAGOYA INST TECHNOL,DEPT BIOSCI,SHOWA KU,GOKISO CHO NAGOYA AICHI 466 JAPAN NAGOYA UNIV,SCH MED,DEPT NEUROL NAGOYA AICHI 466 JAPAN PHARMACIA,RES & DEV MILAN ITALY AICHI MED UNIV,INST MED SCI AGING NAGAKUTE AICHI 48011 JAPAN HAMAMATSU UNIV,SCH MED,DEPT PSYCHOL HAMAMATSU SHIZUOKA 43131 JAPAN KONAN WOMENS COLL,DEPT FOOD & NUTR KONAN JAPAN GIFU PREFECTURE TAJIMI HOSP,DEPT PSYCHIAT TAJIMI JAPAN
Titolo Testata:
Brain research
fascicolo: 2, volume: 709, anno: 1996,
pagine: 285 - 295
SICI:
0006-8993(1996)709:2<285:DET>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE-HYDROXYLASE; INVIVO MICRODIALYSIS; MONOAMINE-OXIDASE; BRAIN; INHIBITION; ALKALOIDS; TETRAHYDROISOQUINOLINE; NEUROTOXINS; METABOLISM; SALSOLINOL;
Keywords:
1(R); ETHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE (N-METHYL-(R)-SALSOLINOL); ANIMAL MODEL; PARKINSONS DISEASE; DOPAMINE; TYROSINE HYDROXYLASE; 6,7-DIHYDROXYISOQUINOLINIUM ION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M. Naoi et al., "DOPAMINE-DERIVED ENDOGENOUS THYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE, N-METHYL-(R)-SALSOLINOL, INDUCED PARKINSONISM IN RAT - BIOCHEMICAL, PATHOLOGICAL AND BEHAVIORAL-STUDIES", Brain research, 709(2), 1996, pp. 285-295

Abstract

Dopamine-derived thyl-6,7-dihydroxy-1,2,3,4-tetrahydrosisopuinoline (salsolinol, Sal) and related compounds were examined for their selective neurotoxicity to dopamine neurons by injection into the rat striatum. Among salsolinol analogs examined, only N-methyl-(R)-salsolinol (NM(R)Sal) induced behavioral changes very similar to those in Parkinson's disease: hypokinesia, stiff tail, limb twitching at rest and postural abnormality. Biochemical analysis showed that after NM(R)Sal injection, NM(R)Sal itself and its oxidation product, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion (DMDHIQ(+)) accumulated in the striatum, and also in the substantia nigra definite amount of DMDHIQ(+) was detected. Dopamine and noradrenaline were reduced in the striatum and more markedly in the substantia nigra, whereas serotonin and its metabolite were not affected. Morphological analysis revealed selective reduction of tyrosine hydroxylase (TH)-containing neurons in the substantia nigra after continuous NM(R)Sal administration in the striatum. These results demonstrate the selective cytotoxicity of NM(R)Sal to the dopamine neurons in the substantia nigra, and the possible involvement of this 6,7-dihydroxyisoquinoline in the pathogenesis of Parkinson's disease is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 21:46:08