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Titolo:
A NONRIBOSOMAL SYSTEM OF PEPTIDE BIOSYNTHESIS
Autore:
KLEINKAUF H; VONDOHREN H;
Indirizzi:
TECH UNIV BERLIN,INST BIOCHEM & MOLEC BIOL,FRANKLINSTR 29 D-10587 BERLIN GERMANY TECH UNIV BERLIN,INST BIOCHEM & MOLEC BIOL D-10587 BERLIN GERMANY
Titolo Testata:
European journal of biochemistry
fascicolo: 2, volume: 236, anno: 1996,
pagine: 335 - 351
SICI:
0014-2956(1996)236:2<335:ANSOPB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAMICIDIN-S SYNTHETASE-2; SYRINGAE PV SYRINGAE; PATHOGEN PSEUDOMONAS-TOLAASII; CYSTEINYL-VALINE SYNTHETASE; ACETYL-COA SYNTHETASE; OPEN READING FRAME; DELTA-(L-ALPHA-AMINOADIPYL)-L-CYSTEINYL-D-VALINE SYNTHETASE; PENICILLIUM-CHRYSOGENUM; STREPTOMYCES-CLAVULIGERUS; ESCHERICHIA-COLI;
Keywords:
BIOSYNTHESIS; MULTIENZYME SYSTEMS; NONRIBOSOMAL PEPTIDE SYNTHESIS; PEPTIDE SYNTHETASES; PEPTIDES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
273
Recensione:
Indirizzi per estratti:
Citazione:
H. Kleinkauf e H. Vondohren, "A NONRIBOSOMAL SYSTEM OF PEPTIDE BIOSYNTHESIS", European journal of biochemistry, 236(2), 1996, pp. 335-351

Abstract

This review covers peptide structures originating from the concerted action of enzyme systems without the direct participation of nucleic acids. Biosynthesis proceeds by formation of linear peptidyl intermediates which may be enzymatically modified as well as transformed into specific cyclic structures. The respective enzyme systems are constructed of biosynthetic modules integrated into multienzyme structures. Genetic and DNA-sequence analysis of biosynthetic gene clusters have revealed extensive similarities between prokaryotic and eukaryotic systems,conserved principles of organisation, and a unique mechanism of transport of intermediates during elongation and modification steps involving 4'-phospho-pantetheine. These similarities permit the identification of peptide synthetases and related aminoacyl-ligases and acyl-ligases from sequence data. Similarities to other biosynthetic systems involved in the assembly of polyketide metabolites are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:57:12