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Titolo:
TOWARD DEVELOPMENT OF AN IMPLANTABLE TISSUE ENGINEERED LIVER
Autore:
DAVIS MW; VACANTI JP;
Indirizzi:
HARVARD UNIV,SCH MED,DEPT SURG,300 LONGWOOD AVE BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT SURG BOSTON MA 02115 CHILDRENS HOSP BOSTON MA 02115 MIT,DEPT CHEM ENGN CAMBRIDGE MA 02139
Titolo Testata:
Biomaterials
fascicolo: 3, volume: 17, anno: 1996,
pagine: 365 - 372
SICI:
0142-9612(1996)17:3<365:TDOAIT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROCARRIER-ATTACHED HEPATOCYTES; AGGREGATE CULTURED-HEPATOCYTES; EXTRACELLULAR-MATRIX; GENE-THERAPY; OVAL CELLS; HEPATOCELLULAR TRANSPLANTATION; BIOARTIFICIAL LIVER; MESSENGER-RNA; RAT SPLEEN; GROWTH;
Keywords:
LIVER TISSUE ENGINEERING; HEPATOCYTE TRANSPLANTATION; IMPLANTABLE DEVICE; MICROCARRIER; ENCAPSULATION; BIODEGRADABLE POLYMER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
M.W. Davis e J.P. Vacanti, "TOWARD DEVELOPMENT OF AN IMPLANTABLE TISSUE ENGINEERED LIVER", Biomaterials, 17(3), 1996, pp. 365-372

Abstract

Hepatocyte transplantation on implantable devices is a tissue engineering approach to improve the treatment of liver disease and the efficacy of ex vivo gene therapy. Diverse physiological functions and high metabolic activity of the liver represent significant challenges to engineering implantable devices that provide long-term hepatic support. Liver tissue engineering research has explored alternatives to direct hepatocyte injection that include hepatocyte attachment to microcarriers, encapsulation and transplantation on biodegradable polymer scaffolds. Successful function of hepatocytes transplanted on implantable devices in animal models has been documented by production of albumin and other liver-specific markers, and clearance of bilirubin and urea metabolites. Strategies used to achieve these successes are reviewed, withparticular emphasis on biodegradable polymer scaffolds, and two areasof investigation that may improve the function of implantable tissue engineered liver devices are highlighted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 15:19:00