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Titolo:
LOCALIZED ADMINISTRATION OF SODIUM-NITROPRUSSIDE - ENHANCES ITS PROTECTION AGAINST PLATELET-AGGREGATION IN STENOSED AND INJURED CORONARY-ARTERIES
Autore:
WILLERSON JT; IGO SR; YAO SK; OBER JC; MACRIS MP; FERGUSON JJ;
Indirizzi:
UNIV TEXAS,SCH MED,DEPT INTERNAL MED,POB 20708 HOUSTON TX 77225
Titolo Testata:
Texas Heart Institute journal
fascicolo: 1, volume: 23, anno: 1996,
pagine: 1 - 8
SICI:
0730-2347(1996)23:1<1:LAOS-E>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC FLOW VARIATIONS; MALIGNANT PERICARDIAL-EFFUSION; VASCULAR SMOOTH-MUSCLE; NITRIC-OXIDE FORMATION; RELAXING FACTOR; L-ARGININE; RECEPTOR ANTAGONISTS; GUANYLATE-CYCLASE; ORGANIC NITRATES; BLOOD-FLOW;
Keywords:
ANIMALS; CORONARY CIRCULATION DRUG EFFECTS; CYCLIC GMP; DOGS; ENDOTHELIUM; VASCULAR; HEMODYNAMICS DRUG EFFECTS; NITRIC OXIDE; NITROPRUSSIDE; INTRAPERICARDIAL; PLATELET AGGREGATION DRUG EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.T. Willerson et al., "LOCALIZED ADMINISTRATION OF SODIUM-NITROPRUSSIDE - ENHANCES ITS PROTECTION AGAINST PLATELET-AGGREGATION IN STENOSED AND INJURED CORONARY-ARTERIES", Texas Heart Institute journal, 23(1), 1996, pp. 1-8

Abstract

Sodium nitroprusside, a potent vasodilator, was evaluated for its effect on platelet aggregation in stenosed and endothelium-injured coronary arteries in a canine model. Twenty-five anesthetized dogs were studied; coronary blood flow velocity was continuously monitored. Recurrent intracoronary platelet aggregation and dislodgment (indicated by cyclic variations in coronary blood flow) were induced by mechanically injuring and stenosing the left anterior descending coronary artery. Sodium nitroprusside was administered either intrapericardially or intravenously 30 min after cyclic flow variations were established. Intrapericardial administration of saline (control) did not affect cyclic flowvariations in any of 6 tested dogs. Sodium nitroprusside abolished cyclic flow variations in ail 7 dogs (100%) when given intrapericardially and in 5 of 7 dogs (71%) when given intravenously (compared to intrapericardial saline, p < 0.01). A smaller dose of sodium nitroprusside was required to abolish cyclic flow variations when given intrapericardial than when given intravenously (1.6 +/- 0.5 mu g . kg(-1). min(-1)vs 4.8 +/- 0.8 mu g . kg(-1). min(-1), p < 0.01). The mean aortic pressure was reduced by 10 to 20 mm Hg after intrapericardial sodium nitroprusside administration and by 30 to 40 mm Hg after intravenous sodium nitroprusside administration. To investigate the mechanism of protection by sodium nitroprusside, N-G-monomethyl-L-arginine, an inhibitor of nitric oxide synthetase, was used to induce cyclic flow variations in mildly injured and stenosed left anterior descending coronary arteries in 5 dogs. Intrapericardial sodium nitroprusside abolished She cyclic flow variations in all 5 dogs. Then oxyhemoglobin, an inhibitor ofnitric oxide, was administered into the left anterior descending coronary arteries of these dogs, and it restored the sodium nitroprusside-abolished cyclic flow variations in all 5 dogs. Thus, sodium nitroprusside protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured canine coronary arteries, probablyby the action of nitric oxide, and it is more effective and hemodynamically safer when administered intrapericardially than when administered intravenously.

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Documento generato il 01/04/20 alle ore 11:40:33