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Titolo:
A DIFFERENT FORM OF LONG-LASTING POTENTIATION REVEALED IN TISSUE-PLASMINOGEN ACTIVATOR MUTANT MICE
Autore:
FREY U; MULLER M; KUHL D;
Indirizzi:
FED INST NEUROBIOL GENE REGULAT & PLAST,BRENNECKESTR 6,POB 1860 D-39008 MAGDEBURG GERMANY UNIV HAMBURG,CTR MOLEC NEUROBIOL D-20246 HAMBURG GERMANY
Titolo Testata:
The Journal of neuroscience
fascicolo: 6, volume: 16, anno: 1996,
pagine: 2057 - 2063
SICI:
0270-6474(1996)16:6<2057:ADFOLP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLS STUDIED INVITRO; TERM POTENTIATION; DENTATE GYRUS; PROTEIN-SYNTHESIS; DENDRITIC INHIBITION; HIPPOCAMPAL SLICE; CA1 REGION; ANISOMYCIN; MEMORY; BLOCKS;
Keywords:
HIPPOCAMPUS; LONG-TERM POTENTIATION; TISSUE PLASMINOGEN ACTIVATOR; NEURONAL PLASTICITY; GABAERGIC TRANSMISSION; GENE INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
U. Frey et al., "A DIFFERENT FORM OF LONG-LASTING POTENTIATION REVEALED IN TISSUE-PLASMINOGEN ACTIVATOR MUTANT MICE", The Journal of neuroscience, 16(6), 1996, pp. 2057-2063

Abstract

The establishment of hippocampal long-term potentiation (LTP) requires protein and mRNA synthesis, suggesting that neuronal activity resulting in LTP initiates a cascade of gene expression. The expression of the gene for the extracellular serine protease tissue plasminogen activator (t-PA) is induced during ITP. Here we analyze long-lasting LTP (L-LTP, >4 hr) in CAI hippocampal slices of mice homozygous for disrupted t-PA genes. Although mutant mice appear to exhibit long-term potentiation, we provide evidence that these mice are devoid of conventional,homosynaptic L-LTP at the Schaffer collateral-CA1 pyramidal cell synapse. Most remarkably, t-PA-deficient mice exhibit a different form of long-lasting potentiation that is characterized by an NMDA receptor-dependent modification of GABA transmission in the CA1 region.

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Documento generato il 09/04/20 alle ore 07:21:41