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Titolo:
EVALUATION OF THE GENERATION OF GENOTOXIC AND CYTOTOXIC METABOLITES OF BENZO[A]PYRENE, AFLATOXIN B-1, NAPHTHALENE AND TAMOXIFEN USING HUMANLIVER-MICROSOMES AND HUMAN-LYMPHOCYTES
Autore:
WILSON AS; TINGLE MD; KELLY MD; PARK BK;
Indirizzi:
UNIV LIVERPOOL,DEPT THERAPEUT & PHARMACOL,POB 147 LIVERPOOL L69 3BX MERSEYSIDE ENGLAND UNIV LIVERPOOL,DEPT THERAPEUT & PHARMACOL LIVERPOOL L69 3BX MERSEYSIDE ENGLAND TOXICOL LABS LTD,DEPT CELL BIOL LEDBURY HR8 1LH HEREFORD ENGLAND
Titolo Testata:
Human & experimental toxicology
fascicolo: 6, volume: 14, anno: 1995,
pagine: 507 - 515
SICI:
0960-3271(1995)14:6<507:EOTGOG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SISTER-CHROMATID EXCHANGES; STABLE METABOLITES; INVITRO; ENZYMES; CYTOCHROME-P-450; CARCINOGENS; ACTIVATION; CHEMICALS; CELLS;
Keywords:
EPOXIDES; BENZO[A]PYRENE; AFLATOXIN B1; NAPHTHALENE; TAMOXIFEN; LIVER; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Wilson et al., "EVALUATION OF THE GENERATION OF GENOTOXIC AND CYTOTOXIC METABOLITES OF BENZO[A]PYRENE, AFLATOXIN B-1, NAPHTHALENE AND TAMOXIFEN USING HUMANLIVER-MICROSOMES AND HUMAN-LYMPHOCYTES", Human & experimental toxicology, 14(6), 1995, pp. 507-515

Abstract

1 The ability of model stable epoxides and metabolites generated by human liver microsomes from benza[a]pyrene, anatoxin B-1, naphthalene and tamoxifen to produce cytotoxicity and genotoxicity in human peripheral lymphocytes has been investigated. 2 The stable epoxides 1,1,1 trichloropropene-2,3-oxide (100 mu M) and trans stilbene oxide (100 mu M)as well as metabolites generated from anatoxin B-1 (30 mu M) and naphthalene (100 mu M) by an extracellular metabolising system were toxic to isolated resting mononuclear leucocytes (MNLs), whereas glycidol (100 mu M), benzo[a]pyrene (100 mu M) and tamoxifen (50 mu M) were not. 3 The stable epoxides 1,1,1 trichloropropene-2,3-oxide (100 mu M) and trans stilbene oxide (100 mu M) but not glycidol (100 mu M) were toxicto dividing lymphocytes only after a 72-h exposure. Tamoxifen (30 mu M), anatoxin B-1 (30 mu M) and their metabolites were also toxic to dividing lymphocytes. Benzo[a]pyrene (100 mu M) and naphthalene (100 mu M) were not toxic either in the absence or presence of the extracellular metabolising system. 4 Benzo[a]pyrene (100 mu M) and aflatoxin B-1 (30 mu M) were directly genotoxic to lymphocytes, this genotoxicity was significantly enhanced by the presence of the extracellular metabolising system. This indicates that both intracellular and extracellular bioactivation of these two compounds can produce genotoxicity. In contrast, naphthalene and tamoxifen were non-genotoxic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:10:40