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Titolo:
ELEVATED PLASMA-LEVELS OF VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1) IN DIABETIC-PATIENTS WITH MICROALBUMINURIA - A MARKER OF VASCULAR DYSFUNCTION AND PROGRESSIVE VASCULAR-DISEASE
Autore:
SCHMIDT AM; CRANDALL J; HORI O; CAO R; LAKATTA E;
Indirizzi:
COLUMBIA UNIV COLL PHYS & SURG,DEPT MED,630 W 168TH ST,P&S 11-518 NEWYORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT SURG NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT PHYSIOL NEW YORK NY 10032 ST LUKES ROOSEVELT HOSP,DEPT MED,JOSLIN DIABET CTR NEW YORK NY 10025 NIA,GERONTOL RES CTR,CARDIOVASC RES LAB BALTIMORE MD 00000
Titolo Testata:
British Journal of Haematology
fascicolo: 3, volume: 92, anno: 1996,
pagine: 747 - 750
SICI:
0007-1048(1996)92:3<747:EPOVCM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELLITUS; ALBUMIN;
Keywords:
GLYCATION; DIABETES; ADHESION MOLECULE; MICROALBUMINURIA; VASCULOPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Schmidt et al., "ELEVATED PLASMA-LEVELS OF VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1) IN DIABETIC-PATIENTS WITH MICROALBUMINURIA - A MARKER OF VASCULAR DYSFUNCTION AND PROGRESSIVE VASCULAR-DISEASE", British Journal of Haematology, 92(3), 1996, pp. 747-750

Abstract

Advanced glycation endproducts (AGEs), which accumulate in diabetic vasculature, result in enhanced expression of endothelial cell-associated vascular cell adhesion molecule-1 (VCAM-1) as well release of a soluble form of VCAM-1 (sVCAM-1) into culture supernatants. We hypothesized that sVCAM-1 in diabetic plasma might reflect early vascular perturbation in diabetic vasculopathy. Diabetic patients with microalbuminuria, a group with a high incidence of vascular complications, had increased plasma levels of sVCAM-1, similar to 1.5-fold greater than diabetic patients without microalbuminuria: P<0.05. sVCAM-1 map be an indicator of ongoing cellular dysfunction in diabetes, as well as a dynamic surrogate marker for the effectiveness of therapeutic interventions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:06:37