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Titolo:
EARLY SUPPRESSIVE EFFECTS OF CHEMOTHERAPY AND CYTOKINE TREATMENT ON COMMITTED VERSUS PRIMITIVE HEMATOPOIETIC PROGENITORS IN PATIENT BONE-MARROW
Autore:
SCHWARTZ GN; HAKIM F; ZUJEWSKI J; SZABO JM; CEPADA R; RISEBERG D; WARREN MK; MACKALL CL; SETZER A; NOONE M; COWAN KH; OSHAUGHNESSY J; GRESS RE;
Indirizzi:
NCI,MED BRANCH,TRANSPLANTAT THERAPY SECT,BLDG 10,ROOM 12N226 BETHESDAMD 20892 OTSUKA PHARMACEUT CO LTD ROCKVILLE MD 00000 NCI,EXPTL IMMUNOL BRANCH BETHESDA MD 20892
Titolo Testata:
British Journal of Haematology
fascicolo: 3, volume: 92, anno: 1996,
pagine: 537 - 547
SICI:
0007-1048(1996)92:3<537:ESEOCA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; TUMOR NECROSIS FACTOR; GRANULOCYTE-MACROPHAGE; CORD BLOOD; PRECURSOR CELLS; GROWTH-FACTORS; TARGET-CELLS; FACTOR-ALPHA; INTERLEUKIN-3; CANCER;
Keywords:
GM-CSF; PIXY321; BONE MARROW LONG-TERM CULTURES; COLONY-FORMING UNITS FOR GRANULOCYTES AND MACROPHAGES; CD34(+) CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
G.N. Schwartz et al., "EARLY SUPPRESSIVE EFFECTS OF CHEMOTHERAPY AND CYTOKINE TREATMENT ON COMMITTED VERSUS PRIMITIVE HEMATOPOIETIC PROGENITORS IN PATIENT BONE-MARROW", British Journal of Haematology, 92(3), 1996, pp. 537-547

Abstract

These studies investigated the effectiveness of in vivo administration of cytokines in ameliorating potential marrow damage induced by chemotherapy. Breast cancer patients received 5-fluorouracil, leucovorin, doxorubicin and cyclophosphamide (FLAC) followed by either GM-CSF, PIXY321, or no cytokine. Marrow was obtained before and after one or two cycles of FLAC once blood cell counts had recovered. Colony-forming units for granulocytes and macrophages (CFU-GM) were used to indicate the effect of therapy on recovery of committed progenitor cells responsible for early blood cell recovery. The frequency and number of CFU-GM in marrow obtained after FLAC + PIXY321 were significantly lower than in marrow obtained after FLAC + GM-CSF or FLAC without cytokine. CD34() cell numbers were also reduced after FLAC + PIXY321. CFU-GM production in marrow long-term cultures (LTC) was used to assess the effect of therapy on primitive progenitors. After 5 weeks the number of CFU-GMin LTC of post-therapy marrow from all three treatment arms was < 15%of the number in pre-therapy LTC. Suppressive effects of FLAC on primitive progenitors were observed even when committed progenitors and CD34(+) cells had recovered to pre-therapy levels. These results demonstrate that cytokine treatment did not ameliorate suppressive or toxic effects of FLAC on the functional integrity of the marrow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 20:45:10