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Titolo:
ELECTROPHORETIC ANALYSIS OF RAT PAROTID SALIVARY PROTEIN-COMPOSITION - INVESTIGATION OF THE PARASYMPATHETIC ATROPINE-RESISTANT SECRETION
Autore:
EKSTROM J; MARSHALL T; TOBIN G; WILLIAMS KM;
Indirizzi:
GOTHENBURG UNIV,DEPT PHARMACOL,MEDICINAREGATAN 7 S-41390 GOTHENBURG SWEDEN UNIV SUNDERLAND,DEPT HLTH SCI SUNDERLAND DURHAM ENGLAND
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 1, volume: 156, anno: 1996,
pagine: 75 - 79
SICI:
0001-6772(1996)156:1<75:EAORPS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVOKED SECRETION; STIMULATION; NERVE;
Keywords:
ATROPINE; BETHANECHOL; ELECTROPHORESIS; PARASYMPATHETIC STIMULATION; RAT PAROTID SALIVA; VASOACTIVE INTESTINAL PEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J. Ekstrom et al., "ELECTROPHORETIC ANALYSIS OF RAT PAROTID SALIVARY PROTEIN-COMPOSITION - INVESTIGATION OF THE PARASYMPATHETIC ATROPINE-RESISTANT SECRETION", Acta Physiologica Scandinavica, 156(1), 1996, pp. 75-79

Abstract

Rats pretreated with atropine and adrenoceptor antagonists show secretion of saliva upon electrical stimulation of the parasympathetic nerve of the parotid gland. The protein composition of this secretion has been analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and compared with the protein profiles obtained with secretions evoked by parasympathetic stimulation (in the absence of atropine) or infusion of bethanechol with or without vasoactive intestinal peptide (VIP, a probable transmitter conveying parasympathetic secretory impulses). The SDS-PAGE patterns were highly reproducible for anindividual rat although minor differences were detected between different rats. The method requires only microlitre volumes of unconcentrated rat saliva and thus is ideal for monitoring sequential aliquots collected from the same rat. The SDS-PAGE patterns indicated (i) little change in the protein profile during prolonged stimulation. (ii) a similar profile with parasympathetic stimulation or infusion of bethanechol. and (iii) a quantitative. rather than qualitative. response to administration of atropine (during parasympathetic stimulation) or VIP (during bethanechol infusion). Thus, the salivary protein composition associated with nonadrenergic. non-cholinergic (NANC) secretion appears similar to that evoked in response to parasympathetic nerve stimulationin the absence of muscarinic receptor blockade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:35:45