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Titolo:
ACTIVATION AND FUNCTION OF NOTCH AT THE DORSAL-VENTRAL BOUNDARY OF THE WING IMAGINAL DISC
Autore:
DECELIS JF; GARCIABELLIDO A; BRAY SJ;
Indirizzi:
UNIV CAMBRIDGE,DEPT ANAT CAMBRIDGE ENGLAND UNIV CAMBRIDGE,DEPT ANAT CAMBRIDGE ENGLAND UNIV CAMBRIDGE,DEPT GENET CAMBRIDGE ENGLAND UNIV AUTONOMA MADRID,CTR BIOL MOLEC E-28049 MADRID SPAIN
Titolo Testata:
Development
fascicolo: 1, volume: 122, anno: 1996,
pagine: 359 - 369
SICI:
0950-1991(1996)122:1<359:AAFONA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEGMENT-POLARITY GENE; LOOP-HELIX PROTEINS; OF-SPLIT COMPLEX; DROSOPHILA-MELANOGASTER; TRANSMEMBRANE PROTEIN; SERRATE ENCODES; LOCUS; EXPRESSION; DELTA; ENHANCER;
Keywords:
DROSOPHILA; NOTCH; DORSAL VENTRAL BOUNDARY; WING; IMAGINAL DISC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Decelis et al., "ACTIVATION AND FUNCTION OF NOTCH AT THE DORSAL-VENTRAL BOUNDARY OF THE WING IMAGINAL DISC", Development, 122(1), 1996, pp. 359-369

Abstract

The cells along the dorsoventral boundary of the Drosophila wing imaginal disc have distinctive properties and their specification requiresNotch activity, Later in development, these cells will form the wing margin, where sensory organs and specialised trichomes appear in a characteristic pattern, We find that Notch is locally activated in these cells, as demonstrated by the restricted expression of the Enhancer ofsplit proteins in dorsal and ventral cells abutting the D/V boundary throughout the third larval instar, Furthermore other genes identifiedby their involvement in Notch signaling during neurogenesis, such as Delta and Suppressor of Hairless, also participate in Notch function at the dorsoventral boundary, In addition, Serrate, a similar transmembrane protein to Delta, behaves as a ligand required in dorsal cells toactivate Notch at the boundary, Notch gain-of-function alleles in which Notch activity is not restricted to the dorsoventral boundary causemiss-expression of cut and wingless and overgrowth of the disc, illustrating the importance of localised Notch activation for wing development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 03:53:39