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Titolo:
GLIDE DIRECTS GLIAL FATE COMMITMENT AND CELL FATE SWITCH BETWEEN NEURONS AND GLIA
Autore:
VINCENT S; VONESCH JL; GIANGRANDE A;
Indirizzi:
UNIV STRASBOURG 1,CNRS,INST GENET & BIOL MOLEC & CELLULAIRE,BP 163 F-67404 ILLKIRCH GRAFFENS FRANCE UNIV STRASBOURG 1,CNRS,INST GENET & BIOL MOLEC & CELLULAIRE F-67404 ILLKIRCH GRAFFENS FRANCE
Titolo Testata:
Development
fascicolo: 1, volume: 122, anno: 1996,
pagine: 131 - 139
SICI:
0950-1991(1996)122:1<131:GDGFCA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; GROWTH CONE GUIDANCE; DROSOPHILA-MELANOGASTER; GENETIC-ANALYSIS; CNS; LINEAGE; EMBRYO; LOCUS; DIFFERENTIATION; GRASSHOPPER;
Keywords:
CELL FATE; GLIOGENESIS; AXONAL GUIDANCE; DROSOPHILA MELANOGASTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
S. Vincent et al., "GLIDE DIRECTS GLIAL FATE COMMITMENT AND CELL FATE SWITCH BETWEEN NEURONS AND GLIA", Development, 122(1), 1996, pp. 131-139

Abstract

Glial cells constitute the second component of the nervous system andare important during neuronal development. In this paper we describe a gene, glial cell deficient, (glide), that is necessary for glial cell fate commitment in Drosophila melanogaster. Mutations at the glide locus prevent glial cell determination in the embryonic central and peripheral nervous system. Moreover, we show that the absence of glial cells is the consequence of a cell fate switch from glia to neurones. This suggests the existence of a multipotent precursor cells in the nervous system, glide mutants also display defects in axonal navigation, which confirms and extends previous results indicating a role for glialcells in these processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:47:57