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Titolo:
INFLUENCE OF GENDER ON SUSCEPTIBILITY TO MULTIPLE-SCLEROSIS AND AGE-OF-ONSET IN CONCORDANT SIBSHIPS
Autore:
WARREN SA; WARREN KG;
Indirizzi:
UNIV ALBERTA,FAC REHABIL MED,ROOM 327,CORBETT HALL EDMONTON AB T6G 2G4 CANADA UNIV ALBERTA,MULTIPLE SCLEROSIS CLIN EDMONTON AB CANADA
Titolo Testata:
International journal of epidemiology
fascicolo: 1, volume: 25, anno: 1996,
pagine: 142 - 145
SICI:
0300-5771(1996)25:1<142:IOGOST>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA; SEX;
Keywords:
MULTIPLE SCLEROSIS; CONCORDANT SIBSHIPS; GENDER; ONSET AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Warren e K.G. Warren, "INFLUENCE OF GENDER ON SUSCEPTIBILITY TO MULTIPLE-SCLEROSIS AND AGE-OF-ONSET IN CONCORDANT SIBSHIPS", International journal of epidemiology, 25(1), 1996, pp. 142-145

Abstract

Background. Research has produced conflicting findings about whether there is an excess of like-sexed pairs among concordant multiple sclerosis (MS) sibships, Although a positive correlation in onset age amongsibling pairs overall has been reported, no data have been published describing age at onset correlations for like-sexed versus unlike-sexed pairs, The purpose of this study was to provide additional information on both issues. Methods. Patients with an MS sibling were sought through the files of the University of Alberta MS Clinic (Edmonton, Canada). The clinic neurologist either reviewed clinical/autopsy material or assessed relatives of index cases prior to accepting the relative as having MS. Pairs of siblings (excluding twins) were divided into (1)male-male pairs, (2) female-female pairs, and (3) female-male pairs. Results. A total of 62 concordant sibling pairs were identified. Therewere 33 like-sexed pairs (6 male-male/27 female-female) and 29 unlike-sexed pairs. The observed number of like-sexed pairs was not significantly different from the expected frequency using 2 x 2 chi(2) analysis, where expected values represent the binomial distribution predictedfrom the frequency of each sex as determined by total number of malesand females. The age at onset intraclass correlation coefficient was -0.09 for sibling pairs overall, -0.22 for like-sexed pairs and +0.02 for unlike-sexed pairs. Conclusions. This study does not provide evidence for an association between disease susceptibility and gender in siblings concordant for MS; nor does it suggest that genetics plays a role in onset age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 07:43:56