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Titolo:
THE EFFECT OF WITHDRAWAL AND REINTRODUCTION OF DEXFENFLURAMINE IN THETREATMENT OF OBESITY
Autore:
DITSCHUNEIT HH; FLECHTNERMORS M; ADLER G;
Indirizzi:
UNIV ULM,DEPT INTERNAL MED,ROBERT KOCH STR 8 D-89081 ULM GERMANY UNIV ULM,DEPT MED W-7900 ULM GERMANY
Titolo Testata:
International journal of obesity
fascicolo: 3, volume: 20, anno: 1996,
pagine: 280 - 282
SICI:
0307-0565(1996)20:3<280:TEOWAR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALORIE;
Keywords:
TREATMENT OF OBESITY; WEIGHT LOSS; DEXFENFLURAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
H.H. Ditschuneit et al., "THE EFFECT OF WITHDRAWAL AND REINTRODUCTION OF DEXFENFLURAMINE IN THETREATMENT OF OBESITY", International journal of obesity, 20(3), 1996, pp. 280-282

Abstract

In this study 25 patients, who had completed the INDEX trial (Guy-Grand at al. Lancet 1989; 2: 1142-1145) were reexamined 2 months after withdrawal of the study medication. The patients then in an open trial received dexfenfluramine (dF) for 6 months. The observed weight gain after withdrawal of study medication was higher in patients treated beforehand with dF (2.6+/-1.2 kg) than in patients who had received placebo (0.8+/-1.0 kg). In the open dF trial rate of weight loss was lower than it had initially been in the patients receiving dF from the outsetof the INDEX trial (13.1+/-4.6 kg within 6 months). In the previous dF treated patients weight loss after re-introduction of dF was 3.7+/-2.7 kg. The previous placebo-treated patients, now receiving dF for thefirst time, lost 4.8+/-1.1 kg. Thus, after withdrawal of dF, patientsexperience weight gain, but after re-introduction of dF, renewed weight loss is achieved. However, the rate of weight loss declines with time.

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Documento generato il 01/12/20 alle ore 07:38:19