Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTICONVULSANT ACTIVITY OF PHENOBARBITAL AND VALPROATE AGAINST MAXIMAL ELECTROSHOCK IN MICE DURING CHRONIC TREATMENT WITH CAFFEINE AND CAFFEINE DISCONTINUATION
Autore:
GASIOR M; BOROWICZ K; BUSZEWICZ G; KLEINROK Z; CZUCZWAR SJ;
Indirizzi:
LUBLIN MED UNIV SCH,DEPT PHARMACOL,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND LUBLIN MED UNIV SCH,DEPT PHARMACOL PL-20090 LUBLIN POLAND LUBLIN MED UNIV SCH,DEPT FORENS MED PL-20090 LUBLIN POLAND
Titolo Testata:
Epilepsia
fascicolo: 3, volume: 37, anno: 1996,
pagine: 262 - 268
SICI:
0013-9580(1996)37:3<262:AAOPAV>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMON ANTIEPILEPTIC DRUGS; INDUCED SEIZURES; INDUCED CONVULSIONS; PROTECTIVE ACTIVITY; AMINOPHYLLINE; RATS; ELECTROCONVULSIONS; DIPHENYLHYDANTOIN; CARBAMAZEPINE; ENPROFYLLINE;
Keywords:
CAFFEINE; PHENOBARBITAL; VALPROATE; CONVULSIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Gasior et al., "ANTICONVULSANT ACTIVITY OF PHENOBARBITAL AND VALPROATE AGAINST MAXIMAL ELECTROSHOCK IN MICE DURING CHRONIC TREATMENT WITH CAFFEINE AND CAFFEINE DISCONTINUATION", Epilepsia, 37(3), 1996, pp. 262-268

Abstract

We evaluated the protective activity (expressed as ED(50) values in mg/kg) of phenobarbital (PB, 120 min before testing) and valproate (30 min) alone or combined with caffeine in male mice with seizures induced by maximal electroshock (MES). Both antiepileptic drugs (AEDs) were administered by intraperitoneal (i.p.) injection in a single dose to mice receiving intraperitoneal caffeine either in a single dose 30 min before the test or as pretreatment every 12 h for 3 and 14 days. In addition, we determined the ED(50) values of the AEDs 24 and 72 h after 14-day treatment with caffeine. Finally, we studied the influence of achallenge dose of caffeine, injected in mice 24 and 72 h after 14 days of treatment with caffeine, on the protective activity of PB or VPA. Caffeine in a single dose of 23.1 mg/kg reduced the anticonvulsant effect of PB. Its protective activity was further impaired after 3 and 14 days of caffeine treatment. The ED(50) for VPA was significantly increased both by the single dose of caffeine and by chronic treatment. The anticonvulsant activity of PB and VPA measured 24 and 72 h after 14-day treatment with caffeine did not differ from control values, but achallenge dose of caffeine injected 24 or 72 h after daily injectionsfor 14 days resulted in a significant reduction in the protective activity of both AEDs. Measurement of the total plasma levels of caffeine, VPA, and PB did not suggest pharmacokinetic interactions as an explanation for our results. Our results indicate that chronic caffeine exposure may progressively reduce the antiepileptic potency of VPA and PB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 11:30:43