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Titolo:
NEITHER PROTEIN-KINASE-C NOR ADENYLATE-CYCLASE ARE ALTERED IN THE STRIATUM FROM SUBJECTS WITH SCHIZOPHRENIA
Autore:
OPESKIN K; DEAN B; PAVEY G; HILL C; KEKS N; COPOLOV D;
Indirizzi:
MENTAL HLTH RES INST VICTORIA,REBECCA L COOPER LABS PARKVILLE VIC AUSTRALIA MENTAL HLTH RES INST VICTORIA,NH & MRC SCHIZOPHRENIA RES UNIT PARKVILLE VIC AUSTRALIA VICTORIAN INST FORENS PATHOL S MELBOURNE VIC 3205 AUSTRALIA ALFRED HOSP,DEPT HOSP & COMMUNITY PSYCHIAT PRAHRAN VIC 3181 AUSTRALIA
Titolo Testata:
Schizophrenia research
fascicolo: 2, volume: 22, anno: 1996,
pagine: 159 - 164
SICI:
0920-9964(1996)22:2<159:NPNAAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTERIOR-PITUITARY CELLS; D2 DOPAMINE-RECEPTORS; BINDING; ALZHEIMERS; INHIBITION; PARKINSONS; DISEASE; SITES;
Keywords:
[H-3] PDBU BINDING; [3H]FORSKOLIN BINDING; SCHIZOPHRENIA; PROTEIN KINASE C; ADENYLATE CYCLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
K. Opeskin et al., "NEITHER PROTEIN-KINASE-C NOR ADENYLATE-CYCLASE ARE ALTERED IN THE STRIATUM FROM SUBJECTS WITH SCHIZOPHRENIA", Schizophrenia research, 22(2), 1996, pp. 159-164

Abstract

Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC)have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizophrenic brain could result in a change in either of these two proteins. Hence we measured PKC and AC in striatum from 20 schizophrenic subjects and 20 non-schizophrenic subjects by quantitative autoradiography and could show no difference in the density of either PKC (436 +/- 35 vs. 485 +/- 29 fmol/mg tissue equivalents (TE), mean +/- SEM) or AC (77+/-9 vs. 80+/-7 fmol/mg TE) in the tissue from schizophrenic compared to the non-schizophrenic subjects. Thus, these data do not support the hypothesis that PKC or AC are changed in the schizophrenic brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:25:19