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Titolo:
TREATMENT WITH L-ARGININE IS LIKELY TO STIMULATE GENERATION OF NITRIC-OXIDE IN PATIENTS WITH PERIPHERAL ARTERIAL OBSTRUCTIVE DISEASE
Autore:
GRYGLEWSKI RJ; GRODZINSKA L; KOSTKATRABKA E; KORBUT R; BIERON K; GOSZCZ A; SLAWINSKI M;
Indirizzi:
JAGIELLONIAN UNIV,COLL MED,DEPT PHARMACOL,16 GRZEGORZECKA PL-31531 KRAKOW POLAND JAGIELLONIAN UNIV,COLL MED,DEPT CLIN PHARMACOL,INST PHARMACOL KRAKOW POLAND
Titolo Testata:
Wiener Klinische Wochenschrift
fascicolo: 4, volume: 108, anno: 1996,
pagine: 111 - 116
SICI:
0043-5325(1996)108:4<111:TWLILT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL DYSFUNCTION; CYCLIC-GMP; INFUSION; NITROVASODILATORS; INSUFFICIENCY; HEMODYNAMICS; PROSTACYCLIN; MOLSIDOMINE; EXERCISE;
Keywords:
ATHEROSCLEROSIS; PERIPHERAL ARTERIAL OBSTRUCTIVE DISEASE; L-ARGININE; NITRIC OXIDE; VASODILATATION; CGMP LEVELS; PLATELET AGGREGABILITY; FIBRINOLYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Gryglewski et al., "TREATMENT WITH L-ARGININE IS LIKELY TO STIMULATE GENERATION OF NITRIC-OXIDE IN PATIENTS WITH PERIPHERAL ARTERIAL OBSTRUCTIVE DISEASE", Wiener Klinische Wochenschrift, 108(4), 1996, pp. 111-116

Abstract

The impairment of endothelial function in hypercholesterolaemic animals and humans is known to be reversed by intravenous infusions of L-arginine (L-ARG), the precursor of NO. 22 patients with peripheral arterial obstructive disease (PAOD) received L-ARG (60 mmol) as intravenousinfusions, each lasting three hours, daily for seven consecutive days. This treatment resulted in elongation of the pain-free and maximum walking distances, as well as shortening of the period of time requiredfor pain relief after walking the maximum distance. A rise in the ankle/arm pressure ratio (AAPR) was associated with an increase of arterial blood flow in both calves. The transcutaneous oxygen tension (tcpO(2)) in the ischaemic foot was also increased. After the Ist and the 7th infusion of L-ARG the spontaneous (PAR) as well as the ADP- and collagen-induced platelet aggregation were suppressed, the euglobulin clotlysis time (ECLT) shortened, plasma levels of platelet activator inhibitor (PAI) decreased. and cGMP levels increased. These data indicate beneficial effects of L-ARG as a therapeutic agent in patients with PAOD. We presume that in these patients high doses of exogenous L-ARG can be partially converted to NO.

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Documento generato il 19/09/20 alle ore 09:33:31