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Titolo:
REMODELING OF THE RADIAL ARTERY IN RESPONSE TO A CHRONIC INCREASE IN SHEAR-STRESS
Autore:
GIRERD X; LONDON G; BOUTOUYRIE P; MOURAD JJ; SAFAR M; LAURENT S;
Indirizzi:
HOP BROUSSAIS,SERV MED INTERNE,DEPT INTERNAL MED,96 RUE DIDOT F-75674PARIS 14 FRANCE HOP BROUSSAIS,SERV MED INTERNE,DEPT INTERNAL MED F-75674 PARIS 14 FRANCE HOP BROUSSAIS,DEPT PHARMACOL PARIS FRANCE INSERM,U337 PARIS FRANCE CTR HOSP FH MANHES FLEURY MEROGIS FRANCE
Titolo Testata:
Hypertension
fascicolo: 3, volume: 27, anno: 1996,
parte:, 2
pagine: 799 - 803
SICI:
0194-911X(1996)27:3<799:ROTRAI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; HYPERTENSION; PROLIFERATION; DIAMETER; GRAFTS;
Keywords:
ARTERIES; KIDNEY; HEMODYNAMICS; BLOOD FLOW VELOCITY; ARTERIOVENOUS FISTULA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
X. Girerd et al., "REMODELING OF THE RADIAL ARTERY IN RESPONSE TO A CHRONIC INCREASE IN SHEAR-STRESS", Hypertension, 27(3), 1996, pp. 799-803

Abstract

Chronic changes in large artery blood flow rates induce correspondingadjustments in arterial diameter, but little is known about structural adaptations of the vessel wall in humans. We used a high-resolution echo-tracking system to measure radial artery internal diameter, wall thickness, and mean blood flow on both arms of 11 patients with end-stage renal disease. Measurements were performed on the wrist side of the arteriovenous fistula. The contralateral radial artery was investigated as control. Wall cross-sectional area, circumferential wall stress, and mean wall shear stress were calculated. Results indicate a sixfold increase in blood flow on the side of the arteriovenous fistula compared with the control side, with a 1.4-fold increase in internal diameter. The diameter enlargement was sufficient to normalize wall shear stress. Changes in diameter were not associated with arterial wall hypertrophy because wall cross-sectional area was not increased and rather suggest a ''remodeling'' of the arterial wall. For the same level ofblood pressure, circumferential wall stress was increased on the sideof the arteriovenous fistula. These results suggest that the structural adaptations of the arterial wall to a chronic increase in blood flow normalize wall shear stress and overcome stretch-induced changes in the particular circumstance of arteriovenous fistula.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:56:19