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Titolo:
THE OCCURRENCE OF SERUM AUTOANTIBODIES AGAINST ENOLASE IN CANCER-ASSOCIATED RETINOPATHY
Autore:
ADAMUS G; APTSIAURI N; GUY J; HECKENLIVELY J; FLANNERY J; HARGRAVE PA;
Indirizzi:
GOOD SAMARITAN HOSP,RS DOW NEUROL SCI INST PORTLAND OR 97209 UNIV FLORIDA,COLL MED,DEPT OPHTHALMOL GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,DEPT BIOCHEM & MOL BIOL GAINESVILLE FL 32610 UNIV CALIF LOS ANGELES,MED CTR,JULES STEIN EYE INST LOS ANGELES CA 90024 UNIV CALIF BERKELEY,SCH OPTOMETRY BERKELEY CA 94720
Titolo Testata:
Clinical immunology and immunopathology
fascicolo: 2, volume: 78, anno: 1996,
pagine: 120 - 129
SICI:
0090-1229(1996)78:2<120:TOOSAA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL-CELL-CARCINOMA; NEURON-SPECIFIC ENOLASE; LUNG-CANCER; PHOTORECEPTOR DEGENERATION; PARANEOPLASTIC RETINOPATHY; DISEASE EXTENT; ANTIBODIES; ELECTROPHORESIS; PROTEINS; MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G. Adamus et al., "THE OCCURRENCE OF SERUM AUTOANTIBODIES AGAINST ENOLASE IN CANCER-ASSOCIATED RETINOPATHY", Clinical immunology and immunopathology, 78(2), 1996, pp. 120-129

Abstract

Cancer-associated retinopathy (CAR) is an uncommon paraneoplastic disease in which degeneration of the retina occurs as a remote effect of cancer in a distant part of the body. Immunoreactivity of sera from CAR patients and controls have been analyzed. Immunostaining of human retinal proteins showed that a soluble protein of M(r) similar to 46 kDa(p46) is labeled by antibodies from several CAR patients with varioustypes of cancer (lung, breast, bladder, prostate, salivary gland, andgastrointestinal tract cancer and chronic lymphocytic leukemia), These sera did not show reactivity with the 23-kDa protein previously associated with CAR, To identify and further characterize p46, the retinalprotein was purified to homogeneity by anion-exchange chromatography and preparative gel electrophoresis. Protein sequence analysis of the peptides from p46 revealed a high homology with human enolase, an important glycolytic enzyme. Although enolase has been previously identified as a product of several types of tumors, and enolase activity has been detected in the sera of some cancer patients, the existence of autoantibodies directed to enolase has not been described. This is the first report of the presence of serum antibodies to retinal enolase in the patients with cancer and the CAR syndrome, When antibodies of specific isotypes (IgG, IgM, and IgA) were measured, IgG1 isotype was dominant. The significance of these antibodies for the disease process is under investigation. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:08:09