Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INHIBITION OF T-CELL RECRUITMENT AND CUTANEOUS DELAYED-TYPE HYPERSENSITIVITY-INDUCED INFLAMMATION WITH ANTIBODIES TO MONOCYTE CHEMOATTRACTANT PROTEIN-1
Autore:
RAND ML; WARREN JS; MANSOUR MK; NEWMAN W; RINGLER DJ;
Indirizzi:
LEUKOSITE INC,EXPTL THERAPEUT GRP,215 1ST ST CAMBRIDGE MA 02142 LEUKOSITE INC,EXPTL THERAPEUT GRP CAMBRIDGE MA 02142 UNIV MICHIGAN,SCH MED,DEPT PATHOL ANN ARBOR MI 48109
Titolo Testata:
The American journal of pathology
fascicolo: 3, volume: 148, anno: 1996,
pagine: 855 - 864
SICI:
0002-9440(1996)148:3<855:IOTRAC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; BLOOD MONONUCLEAR LEUKOCYTES; ACTIVATING FACTOR MCAF; AMINO-ACID ANALYSIS; IMMUNOPHENOTYPIC CHARACTERIZATION; ATHEROSCLEROTIC LESIONS; LYMPHOCYTE MIGRATION; MONOCLONAL-ANTIBODY; ENHANCED PRODUCTION; LANGERHANS CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Rand et al., "INHIBITION OF T-CELL RECRUITMENT AND CUTANEOUS DELAYED-TYPE HYPERSENSITIVITY-INDUCED INFLAMMATION WITH ANTIBODIES TO MONOCYTE CHEMOATTRACTANT PROTEIN-1", The American journal of pathology, 148(3), 1996, pp. 855-864

Abstract

Leukocytes express chemokine receptors that, upon ligand recognition,are believed to activate and induce the directed migration of these cells from the vasculature to sites of tissue injury. Previous investigations of human and animal inflammatory tissue have revealed that expression of chemokines can be increased in association with leukocyte infiltration. Monocyte chemotactic protein-1 (MCP-1) mediates monocyte chemotaxis in vitro and migration of monocytes to inflammatory sites invivo. More recently, T cell chemotaxis to MCP-1 has been observed in vitro, but the contribution of this protein to T cell migration in vivo and to lymphocyte-mediated inflammation has not been determined. In this report, we show that using a rat model of cutaneous delayed hypersensitivity, MCP-1 expression correlates spatially and kinetically with T cell and monocyte recruitment and that antibodies directed to MCP-1 when administered therapeutically to animals undergoing delayed hypersensitivitly can almost completely abolish T cell migration and inflammatory sequelae. Moreover, the concentration of antibody needed to inhibit T cell trafficking to inflammatory sites is almost one order of magnitude lower than that needed to impede monocyte recruitment. Therefore, MCP-1 is functionally relevant in the genesis of delayed hypersensitivity and may be a useful therapeutic target for diseases mediatedin part by T lymphocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:15:06