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Titolo:
GR-127935 BLOCKS THE LOCOMOTOR AND ANTIDEPRESSANT-LIKE EFFECTS OF RU-24969 AND THE ACTION OF ANTIDEPRESSANTS IN THE MOUSE TAIL SUSPENSION TEST
Autore:
ONEILL MF; FERNANDEZ AG; PALACIOS JM;
Indirizzi:
LILLY RES CTR LTD,ERL WOOD MANOR WINDLESHAM GU20 6PH SURREY ENGLAND LABS ALMIRALL SA E-08024 BARCELONA SPAIN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 3, volume: 53, anno: 1996,
pagine: 535 - 539
SICI:
0091-3057(1996)53:3<535:GBTLAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1 RECEPTOR AGONIST; PHARMACOLOGICAL CHARACTERIZATION; IN-VIVO; RAT; AUTORECEPTOR; RU-24969; RELEASE; MICE; 5-HYDROXYTRYPTAMINE; ANTAGONISTS;
Keywords:
5-HT1B/D; RU 24969; GR 127935; DEPRESSION; LOCOMOTOR ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Oneill et al., "GR-127935 BLOCKS THE LOCOMOTOR AND ANTIDEPRESSANT-LIKE EFFECTS OF RU-24969 AND THE ACTION OF ANTIDEPRESSANTS IN THE MOUSE TAIL SUSPENSION TEST", Pharmacology, biochemistry and behavior, 53(3), 1996, pp. 535-539

Abstract

The 5-HT1A/B agonist RU 24969 induces hyperactivity in rodents and also shows antidepressant like effects in some animal models of depression. We have examined the effects of selective antagonists at 5-HT1A and 5-HT1B/D receptors (WAY 100135 and GR 127935, respectively) on both the hyperlocomotor and anti-immobility effects of RU 24969. While a high dose of WAY 100135 (10 mg/kg) had no effect in either paradigm, GR 127935 attenuated the behavioural effects of RU 24969 in both. WAY 100135 was also without effect on the antidepressant effect of paroxetine, while GR 127935 blocked the effects of paroxetine (1 mg/kg) and imipramine (10 mg/kg). Furthermore, while coadministration of paroxetine or imipramine enhanced the effects of RU 24969 in the mouse tail suspension test, imipramine had no effect on the locomotor activating effects of the 5-HT1B agonist, suggesting different neural substrates may underly the effects in the different tests. These studies indicate a role for the 5-HT1B/D receptor in the mediation of the effects of antidepressant treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:53:17