Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GENETIC-ANALYSIS OF SEX AND GENERATION DIFFERENCES IN PLASMA-LIPID, LIPOPROTEIN, AND APOLIPOPROTEIN LEVELS IN ADOLESCENT TWINS AND THEIR PARENTS
Autore:
BOOMSMA DI; KEMPEN HJM; LEUVEN JAG; HAVEKES L; DEKNIJFF P; FRANTS RR;
Indirizzi:
FREE UNIV AMSTERDAM,DEPT PHYSIOL PSYCHOL,DE BOELELAAN 1111 1081 HV AMSTERDAM NETHERLANDS NETHERLANDS ORG APPL SCI RES PREVENT & HLTH LEIDEN NETHERLANDS LEIDEN UNIV,DEPT HUMAN GENET LEIDEN NETHERLANDS
Titolo Testata:
Genetic epidemiology
fascicolo: 1, volume: 13, anno: 1996,
pagine: 49 - 60
SICI:
0741-0395(1996)13:1<49:GOSAGD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY LIPOPROTEIN; CORONARY-ARTERY DISEASE; A-I; RISK-FACTORS; B LEVELS; CHOLESTEROL; SERUM; ATHEROSCLEROSIS; HERITABILITY;
Keywords:
HERITABILITY; CHOLESTEROL; TRIGLYCERIDES; HDL; LDL; APOA1; APOA2; APO-B; APOE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
D.I. Boomsma et al., "GENETIC-ANALYSIS OF SEX AND GENERATION DIFFERENCES IN PLASMA-LIPID, LIPOPROTEIN, AND APOLIPOPROTEIN LEVELS IN ADOLESCENT TWINS AND THEIR PARENTS", Genetic epidemiology, 13(1), 1996, pp. 49-60

Abstract

In a sample of Dutch families consisting of parents aged 35-65 years and their twin offspring aged 14-21 years, a significant difference between generations was observed in phenotypic variances and in genetic heritabilities for plasma levels of total cholesterol, triglycerides, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol, and apolipoproteins (ape) A1, A2, B, and E. For all traits parents were more variable than their offspring. This increase in phenotypic variance was best explained by a genetic model in which individualspecific environmental variance increased with increasing age. Genetic variance was the same across generations for nearly all traits except triglycerides and apoE, for which a decrease in genetic variance wasobserved. This model led to large intergenerational differences in genetic heritabilities. Heritabilities for children were between 65 and 87%, while heritabilities for their parents were between 10 and 50%. No evidence was found for effects of a shared family environment. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:37:24