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Titolo:
ANGIOTENSINASE-A GENE-EXPRESSION AND ENZYME-ACTIVITY IN ISOLATED GLOMERULI OF DIABETIC RATS
Autore:
THAISS F; WOLF G; ASSAD N; ZAHNER G; STAHL RAK;
Indirizzi:
UNIV HAMBURG,HOSP EPPENDORF,DEPT INTERNAL MED,DIV NEPHROL & OSTEOL,MARTINISTR 52 D-20246 HAMBURG GERMANY UNIV HAMBURG HOSP,DEPT INTERNAL MED,DIV NEPHROL W-2000 HAMBURG GERMANY UNIV FRANKFURT KLINIKUM,DEPT INTERNAL MED,DIV NEPHROL W-6000 FRANKFURT GERMANY
Titolo Testata:
Diabetologia
fascicolo: 3, volume: 39, anno: 1996,
pagine: 275 - 280
SICI:
0012-186X(1996)39:3<275:AGAEII>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINOPEPTIDASE-A; RENAL INJURY; RENIN; KIDNEY; MELLITUS; SYSTEM; NEPHROPATHY;
Keywords:
DIABETIC NEPHROPATHY; RENIN ANGIOTENSIN SYSTEM; ANGIOTENSINASE A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
F. Thaiss et al., "ANGIOTENSINASE-A GENE-EXPRESSION AND ENZYME-ACTIVITY IN ISOLATED GLOMERULI OF DIABETIC RATS", Diabetologia, 39(3), 1996, pp. 275-280

Abstract

One of the characteristics of early diabetic nephropathy is glomerular hyperfiltration and hyperperfusion. Many factors have been suggestedto induce glomerular hyperperfusion among which are an increased production of vasodilatory prostanoids, an increased synthesis of nitric oxide, a reduced responsiveness of afferent glomerular arterioles to vasoconstrictor stimuli due to diabetic metabolic disturbances and a decreased receptor density for angiotensin II. It has been known for years that angiotensin II is formed locally due to the local activation ofthe renin angiotensin system. The local angiotensin II concentration,however, is not only regulated by the synthesis rate but also by the local degradation through activation of an aminopeptidase. The main finding of the present study was that the mRNA expression and activity of the angiotensin II degrading enzyme, angiotensinase A, was increasedtwofold in diabetic rats at 5 weeks and that the increase in mRNA expression was suppressed by insulin therapy and short-term treatment with the angiotensin II antagonist saralasin, whereas angiotensinase A enzyme activity was only reduced by saralasin and not by insulin. These results demonstrate that the angiotensin II degrading exopeptidase angiotensinase A is activated in diabetic glomeruli. This increased activity may be an additional mechanism to explain glomerular hyperfiltration and hyperperfusion in early diabetic nephropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:50:45