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Titolo:
LACK OF INTERACTION BETWEEN VALACICLOVIR, THE L-VALYL ESTER OF ACYCLOVIR, AND MAALOX ANTACID
Autore:
DEBONY F; BIDAULT R; PECK R; POSNER J;
Indirizzi:
LABS WELLCOME,DEPT CLIN PHARMACOL,20 RUE ROUGET LISLE F-92442 ISSY MOULINEAUX FRANCE WELLCOME RES LABS,DEPT CLIN PHARMACOL BECKENHAM BR3 3BS KENT ENGLAND
Titolo Testata:
Journal of antimicrobial chemotherapy
fascicolo: 2, volume: 37, anno: 1996,
pagine: 383 - 387
SICI:
0305-7453(1996)37:2<383:LOIBVT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREVENTION; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
F. Debony et al., "LACK OF INTERACTION BETWEEN VALACICLOVIR, THE L-VALYL ESTER OF ACYCLOVIR, AND MAALOX ANTACID", Journal of antimicrobial chemotherapy, 37(2), 1996, pp. 383-387

Abstract

Valaciclovir is rapidly and extensively converted to acyclovir. In this study we investigated the potential interaction between oral valaciclovir and Maalox. On each of three occasions 18 healthy volunteers received a single oral dose of 1000 mg, valaciclovir, or 30 mL Maalox 65min after valacicolovir administration, or 30 mL Maalox 30 min beforevalaciclovir. Acyclovir plasma concentrations and pharmacokinetic parameters were not significantly affected by administration of Maalox before or after valaciclovir. Therefore, there is no need for restriction of valaciclovir dosing in patients receiving antacid medication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:27:51