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Titolo:
THE ROLE OF VIRAL DIVERSITY IN HIV PATHOGENESIS
Autore:
GOUDSMIT J;
Indirizzi:
ACAD MED CTR,HUMAN RETROVIRUS LAB,MEIBERGDREEF 15 1105 AZ AMSTERDAM NETHERLANDS
Titolo Testata:
Journal of acquired immune deficiency syndromes and human retrovirology
, volume: 10, anno: 1995, supplemento:, 1
pagine: 15 - 19
SICI:
1077-9450(1995)10:<15:TROVDI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; BIOLOGICAL PHENOTYPE; INFECTION; TYPE-1; PROGRESSION; INDIVIDUALS; AIDS; QUANTITATION; EXPRESSION; CORRELATE;
Keywords:
HIV; SEROCONVERSION; CD4 CELL COUNTS; VIRAL PHENOTYPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J. Goudsmit, "THE ROLE OF VIRAL DIVERSITY IN HIV PATHOGENESIS", Journal of acquired immune deficiency syndromes and human retrovirology, 10, 1995, pp. 15-19

Abstract

From the time of seroconversion, patients who retain a high viral load are known to progress more rapidly to AIDS than individuals who havelower levels of HIV. Increased viral load is accompanied by decreasing CD4 cell numbers, and CD4 cell counts are therefore widely used as adiagnostic marker or predictor of progression in HIV patients. Duringthe asymptomatic phase, however, CD4 counts often remain in the ''normal'' range, and this marker provides little information on potential disease progression. A shift in viral phenotype from non-syncytium-inducing (NSI) to syncytium-inducing (SI) heralds disease progression, and early in infection SI progression can be distinguished from nonprogression on the basis of CD4 changes. NSI progression, on the other hand, cannot be distinguished from nonprogression on the basis of CD4 counts but can be distinguished on the basis of RNA load. Molecular assessment of viral phenotype, such as quantitative measures of HIV RNA, as well as syncytium-inducing and nonsyncytium-inducing is therefore ableto provide valuable information on the probable course of progressionin individual patients, thus aiding in more effective disease management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 05:50:08