Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SELECTIVE DEATH OF HIPPOCAMPAL CA3 PYRAMIDAL CELLS WITH MOSSY FIBER AFFERENTS AFTER CRH-INDUCED STATUS EPILEPTICUS IN INFANT RATS
Autore:
RIBAK CE; BARAM TZ;
Indirizzi:
UNIV CALIF IRVINE,DEPT ANAT & NEUROBIOL IRVINE CA 92717 UNIV CALIF IRVINE,DEPT PEDIAT IRVINE CA 92717
Titolo Testata:
Developmental brain research
fascicolo: 2, volume: 91, anno: 1996,
pagine: 245 - 251
SICI:
0165-3806(1996)91:2<245:SDOHCP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; CORTICOTROPIN-RELEASING HORMONE; SYNAPTIC REORGANIZATION; KAINIC ACID; DENTATE GYRUS; SEIZURES;
Keywords:
EPILEPSY; INFANT; RAT; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
C.E. Ribak e T.Z. Baram, "SELECTIVE DEATH OF HIPPOCAMPAL CA3 PYRAMIDAL CELLS WITH MOSSY FIBER AFFERENTS AFTER CRH-INDUCED STATUS EPILEPTICUS IN INFANT RATS", Developmental brain research, 91(2), 1996, pp. 245-251

Abstract

Previous studies of CRH-induced status epilepticus in infant rats demonstrated neuronal loss in several limbic structures, including the CA3 region of the hippocampus. The goal of the present study was to identify the neurons affected by CRH-induced seizures and determine whether they formed synapses with afferent axon terminals. Clusters of neurons in the CA3 region of the hippocampus were osmiophilic when viewed in thick sections. Semi-thin 2-mu m sections of the pyramidal cell layer contained dark, shrunken neurons with apical and basal dendrites among normal appearing pyramidal cells. Electron microscopy revealed degenerating pyramidal cells with intact cell membranes and electron densenuclei and cytoplasm. The shrunken dendrites of these cells had spines and were postsynaptic to large immature-appearing messy fibers. Thus, CA3 pyramidal neurons that are linked via messy fibers to the tri-synaptic excitatory hippocampal circuit die subsequent to CRH-induced status epilepticus. The shrunken appearance and selective loss of these neurons are incompatible with necrosis as the mechanism of degeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:21:00