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Titolo:
SLOW ASSOCIATION OF POSITIVELY CHARGED CA2-SITES IN RAT-BRAIN MEMBRANES( CHANNEL ANTAGONIST AMLODIPINE TO DIHYDROPYRIDINE RECEPTOR)
Autore:
QU YL; SUGIYAMA K; HATTORI K; YAMAMOTO A; WATANABE K; NAGATOMO T;
Indirizzi:
NIIGATA COLL PHARM,DEPT PHARMACOL,5-13-2 KAMISHINEI CHO NIIGATA 96021JAPAN NIIGATA COLL PHARM,DEPT PHARMACOL NIIGATA 96021 JAPAN TSUBAME ROSAI HOSP,RES LABS,DIV CARDIOVASC TSUBAME NIIGATA 95912 JAPAN
Titolo Testata:
General pharmacology
fascicolo: 1, volume: 27, anno: 1996,
pagine: 137 - 140
SICI:
0306-3623(1996)27:1<137:SAOPCC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOLIGAND BINDING ASSAY; VASCULAR SMOOTH-MUSCLE; BLOCKING PROPERTIES; CALCIUM; LOCATION; INVITRO; SM-6586; CELLS; HEART;
Keywords:
AMLODIPINE; CA2+ ANTAGONISTS; H-3 PN200-110; PH DEPENDENCE; RAT BRAIN; SLOW ASSOCIATION; SLOW ONSET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
Y.L. Qu et al., "SLOW ASSOCIATION OF POSITIVELY CHARGED CA2-SITES IN RAT-BRAIN MEMBRANES( CHANNEL ANTAGONIST AMLODIPINE TO DIHYDROPYRIDINE RECEPTOR)", General pharmacology, 27(1), 1996, pp. 137-140

Abstract

1. No significant differences were observed in K-d and B-max values between pH 7.2 (0.16 +/- 0.01 nM and 155.36 +/- 16.07 fmol/mg protein) and pH 10.0(0.15 +/- 0.01 nM and 158.63 +/- 13.80 fmol/mg protein) in rat brain membranes. 2. The IC50 ratios at 0- and 270-min preincubations of amlodipine and manidipine at pH 7.2 were 23.09 and 10.25, respectively, whereas these ratios for these two drugs at pH 10.0 mere 2.63 and 1.34, respectively. 3. In contrast, on treatment with nisoldipine,benidipine, SM-6586 and nifedipine, no significant differences were observed in the IC50 ratios between 0- and 270-min preincubations at pH7.2 and 10.0.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:41:48