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Titolo:
PHARMACOLOGICAL THERAPIES OF INTESTINAL R EPERFUSION INJURY IN ANIMAL-EXPERIMENTS
Autore:
LEHMANN C; LUTHER B; KOX WJ;
Indirizzi:
FREE UNIV BERLIN,KLINIKUM CHARITE,KLIN ANAESTHESIOL & INTENS THERAPIE,SCHUMANNSTR 20-21 D-10117 BERLIN GERMANY
Titolo Testata:
Zentralblatt fur Chirurgie
fascicolo: 1, volume: 121, anno: 1996,
pagine: 70 - 76
SICI:
0044-409X(1996)121:1<70:PTOIRE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
GER
Soggetto:
ISCHEMIA-REPERFUSION; SUPEROXIDE-DISMUTASE; POSTISCHEMIC REPERFUSION; LIPID-PEROXIDATION; XANTHINE-OXIDASE; SKELETAL-MUSCLE; RADICALS; INHIBITION; REDUCTION; ILOPROST;
Keywords:
ISCHEMIA; REPERFUSION; INTESTINE; ANIMAL EXPERIMENTS; RADICAL SCAVENGER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
C. Lehmann et al., "PHARMACOLOGICAL THERAPIES OF INTESTINAL R EPERFUSION INJURY IN ANIMAL-EXPERIMENTS", Zentralblatt fur Chirurgie, 121(1), 1996, pp. 70-76

Abstract

Summ.: We evaluated experimentally (80 Lewis-rats) possible pharmacological strategies in the treatment of intestinal reperfusion injury inhypo- and normothermia. We used a specific perfusion solution containing PGI, or radical scavengers (superoxide dismutase, oxypurinol, tocopherol, ascorbate). Decreased malondialdehyde (MDA) plasma release after reperfusion proved the antioxidative efficiency of the administeredradical scavengers (normothermia - control group: MDA increase after 15 min of reperfusion to 160 +/- 30 % compared to level at the end of ischemia, oxypurinol: 110 +/- 23 %, tocopherol: 112 +/- 12 %, ascorbate: 104 +/- 20 %; p < 0,05), The ATP/ADP-ratio of the therapy groups was stable In contrast to the control group. Alkaline phosphatase release was significantly diminished under radical scavenger administration (normothermia/l5 min reperfusion - control group: 7,7 +/- 0,9 mu mol/ls, oxypurinol: 4,4 +/- 0,4 mu mol/ls, tocopherol: 3,5 +/- 0,1 mu mol/ls, ascorbate: 5,9 +/- 0,3 mu mol/ls; p < 0,05). Histologically we observed a mucosa protective effect particularly in the ascorbate group. Other pharmacological strategies are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 23:16:52