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Titolo:
A PROSPECTIVE VIEW ON PHOSPHATASES AND REPLICATIVE SENESCENCE
Autore:
BERNIER L; WANG E;
Indirizzi:
SIR MORTIMER B DAVIS JEWISH HOSP,LADY DAVIS INST MED RES,BLOOMFIELD CTR RES AGING MONTREAL PQ H3T 1E2 CANADA SIR MORTIMER B DAVIS JEWISH HOSP,LADY DAVIS INST MED RES,BLOOMFIELD CTR RES AGING MONTREAL PQ H3T 1E2 CANADA MCGILL UNIV MONTREAL PQ H3T 1E2 CANADA
Titolo Testata:
Experimental gerontology
fascicolo: 1-2, volume: 31, anno: 1996,
pagine: 13 - 19
SICI:
0531-5565(1996)31:1-2<13:APVOPA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE-PHOSPHATASE; HUMAN-FIBROBLASTS; TRANSFORMATION; OVEREXPRESSION; KINASES; P34CDC2; CDC25;
Keywords:
PHOSPHASTASES; SENSESCENCE; HOMEOSTASIS; PHOSPHORYLATION; CELL CYCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
L. Bernier e E. Wang, "A PROSPECTIVE VIEW ON PHOSPHATASES AND REPLICATIVE SENESCENCE", Experimental gerontology, 31(1-2), 1996, pp. 13-19

Abstract

Addition of phosphate to proteins by kinases, or its removal by phosphatases, is probably the control mechanism most often used by cells tomaintain homeostasis. This mechanism presents the advantage of being fast, versatile, and easily reversible. It is used by all organisms from bacteria to man. Although more is known about the kinases, recent studies are beginning to shed light on the role of phosphatases, the enzymes that are responsible for terminating the effects of phosphorylation. These enzymes are perfect candidates for controlling all the crucial check points during cell cycle traverse, and as such, will be found to be responsible for many important decision in the life of a cell,including entry into replicative senescence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:59:10