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Titolo:
DIETARY-CHOLESTEROL ENHANCES IMPAIRED ENDOTHELIUM-DEPENDENT RELAXATIONS IN AORTAS OF SALT-INDUCED HYPERTENSIVE DAHL RATS
Autore:
KITAGAWA S; YAMAGUCHI Y; SHINOZUKA K; KWON YM; KUNITOMO M;
Indirizzi:
MUKOGAWA WOMENS UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,11-68 KOSHIEN KYUBAN CHO NISHINOMIYA HYOGO 663 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 1-2, volume: 297, anno: 1996,
pagine: 71 - 76
SICI:
0014-2999(1996)297:1-2<71:DEIER>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; GENETIC-HYPERTENSION; RABBIT AORTA; ACETYLCHOLINE; ARTERIES; HYPERCHOLESTEROLEMIA; CONTRACTIONS; RESPONSES; RISK;
Keywords:
DAHL SALT-SENSITIVE RAT; ENDOTHELIUM-DEPENDENT RELAXATION; HIGH-CHOLESTEROL DIET; HYPERCHOLESTEROLEMIA; HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S. Kitagawa et al., "DIETARY-CHOLESTEROL ENHANCES IMPAIRED ENDOTHELIUM-DEPENDENT RELAXATIONS IN AORTAS OF SALT-INDUCED HYPERTENSIVE DAHL RATS", European journal of pharmacology, 297(1-2), 1996, pp. 71-76

Abstract

We investigated the effect of hypercholesterolemia on the vascular reactivity of thoracic aortas isolated from hypertensive Dahl salt-sensitive (DS) rats. DS rats were fed on a low-sodium diet (control group),a low-sodium plus high-cholesterol diet (CHOL group), a high-sodium diet (NaCl group) or a high-sodium plus high-cholesterol diet (NaCl + CHOL group) for 8 weeks. Hypercholesterolemia developed in the CHOL andNaCl + CHOL groups, while hypertension developed in the NaCl and NaCl+ CHOL groups, with these changes being greatest in the NaCl + CHOL group. Aortic cholesteryl ester accumulation was observed only in the NaCl + CHOL group. Endothelium-dependent relaxations in response to acetylcholine were significantly attenuated in the aortic rings from the NaCl and NaCl + CHOL groups, compared to the control group. The degreeof attenuation in the NaCl + CHOL group was significantly greater than that in the NaCl group. Endothelium-dependent relaxations induced bythe calcium ionophore A23187 were attenuated only in the NaCl + CHOL group. Endothelium-independent relaxations in response to sodium nitroprusside were slightly but significantly attenuated in the NaCl + CHOLgroup. The relaxations in the CHOL group were comparable to those in the control group. These findings indicate that cholesterol feeding strikingly enhances the impaired endothelium-dependent relaxations and the slightly impaired endothelium-independent relaxations in the aorta of DS rats with salt-induced hypertension, parallel to the developmentof hypertension, hypercholesterolemia and cholesterol deposition.

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Documento generato il 28/11/20 alle ore 01:03:19