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Titolo:
REVERSAL OF RESERPINE-INDUCED CATALEPSY BY SELECTIVE D1 AND D2 DOPAMINE AGONISTS
Autore:
HUBBARD CA; TRUGMAN JM;
Indirizzi:
UNIV VIRGINIA,HLTH SCI CTR,DEPT NEUROL,BOX 394 CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,HLTH SCI CTR,DEPT NEUROL,BOX 394 CHARLOTTESVILLE VA 22908
Titolo Testata:
Movement disorders
fascicolo: 4, volume: 8, anno: 1993,
pagine: 473 - 478
SICI:
0885-3185(1993)8:4<473:RORCBS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; CY 208-243; ANTIPARKINSONIAN ACTIVITY; RECEPTOR STIMULATION; TREATED MOUSE; D-1; LEVODOPA; RATS; MPTP; LESIONS;
Keywords:
ALPHA-METHYL-P-TYROSINE; CATALEPSY; D1 AND D2 DOPAMINE AGONIST; RAT; RESERPINE; PARKINSONISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Hubbard e J.M. Trugman, "REVERSAL OF RESERPINE-INDUCED CATALEPSY BY SELECTIVE D1 AND D2 DOPAMINE AGONISTS", Movement disorders, 8(4), 1993, pp. 473-478

Abstract

To gain insight into the antiparkinsonian effects of selective D1 andD2 dopamine receptor stimulation, we examined the ability of D1 (SKF 38393) and D2 (quinpirole) agonists to reverse catalepsy induced by the combined administration of reserpine and alpha-methyl-p-tyrosine (AMPT) in rats. Catalepsy, the failure to correct an externally imposed posture, is a measure of akinesia and was assessed using the bar test. Rats injected with reserpine alone (2.5 mg/kg i.p.) developed akinesiaand ptosis within 60-90 min. The D1 agonist SKF 38393 (30 mg/kg i.v.)rapidly reversed ptosis and restored near-normal mobility when administered 24 h after reserpine and AMPT; catalepsy was reversed for 90 min, after which the drug effect wore off. Quinpirole (1 mg/kg i.v.) reversed catalepsy for the duration of the test period (4 h) but did not consistently reverse ptosis or promote normal mobility; the rats continued to exhibit kyphotic postures with little spontaneous locomotion. These results indicate that selective D1 stimulation is sufficient to reverse reserpine-induced akinesia and highlight the need for the development of potent selective D1 agonists for clinical trial in Parkinson's disease. In severe dopamine depletion, D2 stimulation alone appears to be insufficient to restore normal movement. Quinpirole, but not SKF 38393, elicited paroxysmal limb/body jerking in reserpine-AMPT-treated rats, providing further evidence that atypical jerking can be elicited by D2 stimulation in the complete absence of D1 stimulation. Thislaboratory observation suggests that some jerking dyskinesias seen intreated parkinsonian patients may be mediated by an imbalance in D1-D2 receptor stimulation.

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Documento generato il 23/01/21 alle ore 03:46:46