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Titolo:
ANALYSIS OF THE DETERMINANTS OF NEUROTROPISM AND NEUROTOXICITY OF HFVIN TRANSGENIC MICE
Autore:
TSCHOPP RR; BRANDNER S; MARINO S; BOTHE K; HORAK I; RETHWILM A; AGUZZI A;
Indirizzi:
UNIV ZURICH,INST NEUROPATHOL,DEPT PATHOL,SCHMELZBERGSTR 12 CH-8091 ZURICH SWITZERLAND UNIV ZURICH,INST NEUROPATHOL,DEPT PATHOL CH-8091 ZURICH SWITZERLAND UNIV WURZBURG,INST VIROL & IMMUNOBIOL D-97078 WURZBURG GERMANY
Titolo Testata:
Virology
fascicolo: 2, volume: 216, anno: 1996,
pagine: 338 - 346
SICI:
0042-6822(1996)216:2<338:AOTDON>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN FOAMY VIRUS; LONG TERMINAL REPEAT; HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN SPUMARETROVIRUS; READING FRAMES; NITRIC-OXIDE; VISNA VIRUS; TRANSACTIVATOR; RETROVIRUS; ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
R.R. Tschopp et al., "ANALYSIS OF THE DETERMINANTS OF NEUROTROPISM AND NEUROTOXICITY OF HFVIN TRANSGENIC MICE", Virology, 216(2), 1996, pp. 338-346

Abstract

The Bel-1 protein of human foamy virus (HFV) is a transactivator acting on the U3 region of the long terminal repeat and on an internal promoter (IP) immediately upstream of the bel genes. An HFV transgene called Delta gpe, containing both promoters and all bet genes, is expressed in the central nervous system and induces neurodegeneration in mice. To dissect the role of individual promoters and bet genes on transgene expression and neurotoxicity we generated transgenic mice with a construct termed pL-bel1, which lacks the IP and the ancillary genes except bel-1. L-bell mice transcribed the HFV transgene in more tissues than Delta gpe mice, suggesting that CNS specificity is dictated by cis-acting elements not present in the pLbel-1 construct Unlike Delta gpemice, L-bel1 mice did not develop neurodegenerative changes and did not show induction of nitric oxide synthase expression, although both strains expressed Bel-1 in the brain. Therefore, Bel-1 expression is not sufficient for neurotoxicity. Our results suggest that Bet, a fusionprotein between bel-1 and bel-2 which is highly expressed in Delta gpe but not in L-bel1 mice, is a candidate for neurotoxicity. (C) 1996 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:16:40