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Titolo:
NEUROSTEROIDAL MODULATION OF SOCIAL ISOLATION-INDUCED DECREASE IN PENTOBARBITAL SLEEP IN MICE
Autore:
MATSUMOTO K; OJIMA K; WATANABE H;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,DIV PHARMACOL,2630 SUGITANI TOYAMA 93001 JAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,DIV PHARMACOL TOYAMA 93001 JAPAN
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 708, anno: 1996,
pagine: 1 - 6
SICI:
0006-8993(1996)708:1-2<1:NMOSID>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; DIAZEPAM BINDING INHIBITOR; A RECEPTOR; RAT-BRAIN; STRESS; PREGNENOLONE; STEROIDS; SULFATE; HORMONE;
Keywords:
SOCIAL ISOLATION STRESS; MOUSE; PENTOBARBITAL SLEEP; CORTICOTROPIN RELEASING FACTOR (CRF); NEUROSTEROID; NORADRENERGIC SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
K. Matsumoto et al., "NEUROSTEROIDAL MODULATION OF SOCIAL ISOLATION-INDUCED DECREASE IN PENTOBARBITAL SLEEP IN MICE", Brain research, 708(1-2), 1996, pp. 1-6

Abstract

Stressful manipulations are known to change the level of neurosteroids capable of interacting with GABA(A) receptor in the brain. To clarify the involvement of these neurosteroids in social isolation stress-induced decrease in pentobarbital sleep in mice, we examined the effectsof 3 beta-hydroxy-5-pregnen-20-one-3-sulfate (pregnenolone sulfate, PS), a steroidal GABA(A) antagonist, and 3 alpha,21-dihydroxy-5 alpha-pregnan-20-one (allo-THDOC) and 3 alpha,21-dihydroxy-5 beta-pregnan-20-one (THDOC), positive allosteric modulators of the GABA(A) receptor, on the hypnotic activity of pentobarbital in socially isolated mice. Pentobarbital (50 mg/kg, i.p.)-induced sleep was significantly shorter in isolated mice than in group-housed mice and adrenalectomy had no effect on the decrease of pentobarbital sleep following social isolation. PS (5-10 mg/kg, i.p. or 12-24 nmol, i.c.v.) decreased pentobarbital sleep in group-housed mice in a dose-dependent manner without affectingthe sleep in socially isolated mice. In contrast, allo-THDOC (14.9-37.4 nmol, i.c.v.) and THDOC (5-12.5 mg/kg, i.p. or 14.9-37.4 nmol, i.c.v.) reversed the pentobarbital sleep decreased by social isolation to the level in group-housed mice. These steroids had no effect on the pentobarbital sleep in group-housed mice. Such a reversing effect of THDOC in isolated mice was significantly blocked by PS (24 nmol, i.c.v.). Moreover, i.c.v. injection of yohimbine (30 nmol), methoxamine (200 nmol) and CRF (2.1 nmol) significantly decreased pentobarbital sleep ingroup-housed mice but not that in isolated mice. The effects of thesedrugs on pentobarbital sleep in group-housed mice were significantly attenuated by THDOC (12.5 mg/kg, i.p.). These results suggest that changes in the level of neurosteroids with ability to modulate GABA(A) receptor function are involved in social isolation-induced decrease in the hypnotic activity of pentobarbital in mice.

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Documento generato il 04/12/20 alle ore 03:34:02